| Project/Area Number |
23659662
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
GOTO YUKINOBU 筑波大学, 医学医療系, 講師 (20451700)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAMATSU Yuji 筑波大学, 医学医療系, 教授 (30302417)
MATSUSHITA Shonosuke 筑波技術大学, 保健科学部, 教授 (70359579)
AGEYAMA Naohide 独立行政法人医薬基盤研究所, 霊長類医科学研究センター, 研究員 (50399458)
HYODO Kazuyuki 大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 講師 (60201729)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 心血管手術 / 補てん素材 / 自己心膜 / TGA / 心膜架橋処理 / GA / 石灰化 / 心臓外科手術 / 心膜 / 架橋処理 / 心臓血管外科手術 |
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| Research Abstract |
TGA treatment resulted in slower increases in Ts of the pericardium, and it required 9 - 12 hours to reach Ts achieved by GA. In subdermal implantation of rat tissues, calcium content was lower in the TGA group than in the GA groups (p < 0.005). The expression site of TN-C and MMP-9 differed from the primary location of calcium deposition in the thoracic aorta treated with TGA suggesting a different underlying mechanism in calcification between GA and TGA crosslinking. TGA crosslinking in the allograft showed superior anti-calcification effect as compared to brief treatment by GA, although TGA crosslinking process was slow.
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