| Project/Area Number |
23659664
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
SUZUKI Motoshi 名古屋大学, 医学系研究科, 講師 (80236017)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Seiichi 名古屋大学, 医学系研究科, 助教 (30584669)
USAMI Noriyasu 名古屋大学、愛知県がんセンター中央病院, 医学部付属病院、呼吸器外科, 助教、医長 (30378179)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌幹細胞 / マーカー / 肺癌 / がん幹細胞 / 分子標的 |
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| Research Abstract |
By using clinical specimens, we performed IHC analysis for the putative cancer-initiating cell markers. Among the markers, we found CD166 may be the mostuseful one. To identify novel lung cancer-initiating cell markers, we analyzed an open database, screened genes that were highly expressed in CD166-positive cells, measured expression levels of such genes in the clinical specimens, and performed shRNA-induced knocking-down experiments. We identified that a gene could be a novel lung cancer-initiating cell marker, as well as a future target for the cancer treatment.
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