| Project/Area Number |
23659669
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAWA Yoshiki 大阪大学, 大学院・医学系研究科, 教授 (00243220)
倉谷 徹 大阪大学, 大学院・医学系研究科, 寄附講座教授 (90448035)
宮川 繁 大阪大学, 大学院・医学系研究科, 講師 (70544237)
吉川 泰司 大阪大学, 大学院・医学系研究科, 助教 (40570594)
福嶌 五月 大阪大学, 大学院・医学系研究科, 助教 (80596867)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | iPS 細胞 / 心筋細胞シート / 心筋梗塞 / 心不全 / iPS細胞 |
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| Research Abstract |
Induced pluripotent stem cells (iPS cells) of human origin were cultivated and differentiated to cardiomyocytes by originally developed protocol. Cardiomyocyte cell-sheet was then generated from the cardiomyocytes derived from the iPS cells. Transplantation of cardiomyocyte cell-sheets into the infarct heart induced functional integration of the iPS cells-derived cardiomyocytes into the cardiac tissue, contributing to functional recovery, in a rat and a porcine model.
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