| Project/Area Number |
23659672
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
SANO Shunji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50235438)
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| Co-Investigator(Renkei-kenkyūsha) |
王 英正 岡山大学, 岡山大学病院, 教授 (50372579)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞外マトリックス / 心臓内幹細胞 / 潅流培養 / バイオ人工心臓 / 人工心筋細胞 / シート工学 |
|---|
| Research Abstract |
The shortage of donors for heart transplantation has become a critical issue to treat the patients with end-stage of cardiac failure. We have decellularized the rat whole heart by using pulsatile perfusion apparatus. Human cardiac progenitor cells were mixed with endothelial progenitor cells inculture and those were perfused to recellularize the acellular construct. Following 8 days in continuous perfusion, reseeded cells were engrafted onto the matrixto reconstruct the entire vascular beds and myocardium ex vivo.
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