| Project/Area Number |
23659677
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
TAKEWA Yoshiaki 独立行政法人国立循環器病研究センター, 研究所, 室長 (20332405)
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| Co-Investigator(Renkei-kenkyūsha) |
TATSUMI Eisuke 国立循環器病研究センター, 研究所, 部長 (00216996)
NAKAYAMA Yasuhide 国立循環器病研究センター, 研究所, 部長 (50250262)
UMEKI Akihide 国立循環器病研究センター, 研究所, 室員 (60596344)
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| Research Collaborator |
SUMIKURA Hirohito 国立循環器病研究センター, 研究所, 研究員 (20433998)
OHNUMA Kentaro 国立循環器病研究センター, 研究所, 研究員 (50527992)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 自家組織 / 大動脈根部 / 組織工学 / 心臓弁 / 生体外組織工学 / バイオリアクター / 再生医療 / ステントバルブ |
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| Research Abstract |
An autologous valved conduit without any artificial support materials (Biovalve) was developed, using in-body tissue engineering. In this study, the potential of the Biovalve as an aortic valve was investigated in a goat model. Biovalves were prepared by 2-month embedding of molds in the subcutaneous space of goats. After removing the molds, Biovalves were made by perfectly autologous connective tissue. Biovalves were implanted as aortic valves using the apico-aortic bypass method for 2 months. Postoperative echocardiogram showed smooth movement of the leaflets with little regurgitation under the systemic circulation. At the sinus portions, marked elastic fibers were formed. The luminal surface was covered with thin pseudointima. In conclusion, completely autologous Biovalves with robust and elastic characteristics satisfied the higher requirements of systemic circulation in goats for 2 months.
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