Neural network scale involved in genesis of hippocampal seizures

• Project/Area Number: 23659681
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: NAKASATO Nobukazu 東北大学, 大学院・医学系研究科, 教授 (80207753)
• Co-Investigator(Renkei-kenkyūsha): JIN Kazutaka 東北大学, 大学院・医学系研究科, 講師 (20436091) ; IWASAKI Masaki 東北大学, 病院, 助教 (00420018)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 機能脳神経外科学 / てんかん / 海馬 / 神経ネットワーク / MRI / 光遺伝学

Research Abstract

This study was aimed to investigate neural network dynamics involved in the genesis of epileptic seizures. We used optogenetically induced model of hippocampal seizures. Multi-contact local field potentials were recorded during induction of hippocampal seizures and the information flow was analyzed statistically. Granger causality analysis revealed importance of information flow along longitudinal hippocampal axis during genesis of epileptic seizures.

Research Products

• [Journal Article] Optogenetically induced Seizure and the Longitudinal Hippocampal Network. (2013)
  • Author(s): Shin-ichiro Osawa, , Hajime Mushiake
  • Journal Title: PLos One Volume: 8 Issue: 4 Pages: 1-1
  • DOI: 10.1371/journal.pone.0060928
  • Peer Reviewed
• [Journal Article] Time-varying inter-hemispheric coherence during corpus callosotomy (2013)
  • Author(s): Okumura E, Iwasaki M, Sakuraba R, Itabashi I, Osawa S, Jin K, Itabashi H, Kato K, Kanno A, Tominaga T, Nakasato N
  • Journal Title: Clin Neurophysiol Volume: (In press) Issue: 11 Pages: 2091-2100
  • DOI: 10.1016/j.clinph.2013.05.004
  • Peer Reviewed
• [Presentation] オプトジェネティクスを用いた海馬発作モデルにおける神経ネットワークの状態遷移 (2013)
  • Author(s): 大沢伸一郎、岩崎真樹、保坂亮介、松坂義哉、富田浩史、石塚徹、菅野江里子、奥村栄一、八尾寛、中里信和、虫明元、冨永悌二
  • Organizer: 第36回日本てんかん外科学会シンポジウム口演
  • Place of Presentation: 岡山
  • Year and Date: 2013-01-17
• [Presentation] オプトジェネティクスを用いた海馬発作モデルにおける神経ネットワークの状態遷移 (2013)
  • Author(s): 大沢伸一郎
  • Organizer: 第36回日本てんかん外科学会
  • Place of Presentation: 岡山
• [Presentation] A novel hippocampal seizure model using optogenetics (2012)
  • Author(s): Shin-ichiro Osawa, Masaki Iwasaki, Ryosuke Hosaka, Yoshiya Matsuzaka, Hiroshi Tomita, Toru Ishizuka, Eriko Sugano, Eiichi Okumura, Hiromu Yawo, Nobukazu Nakasato, Teiji Tominaga, Hajime Mushiake
  • Organizer: 66th Annual Meeting of American Epilepsy Society
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2012-12-01
• [Presentation] オプトジェネティクスを用いた新たなけいれんモデル (2012)
  • Author(s): 大沢伸一郎、岩崎真樹、保坂亮介、松坂義哉、富田浩史、石塚徹、八尾寛、中里信和、虫明元、冨永悌二
  • Organizer: 第89回日本生理学会
  • Place of Presentation: 松本
• [Remarks] 東北大学・大学院医学系研究科・教授 研究者番号: 80207753
  • URL: http://www.epilepsy.med.tohoku.ac.jp/