| Project/Area Number |
23659681
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
JIN Kazutaka 東北大学, 大学院・医学系研究科, 講師 (20436091)
IWASAKI Masaki 東北大学, 病院, 助教 (00420018)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 機能脳神経外科学 / てんかん / 海馬 / 神経ネットワーク / MRI / 光遺伝学 |
|---|
| Research Abstract |
This study was aimed to investigate neural network dynamics involved in the genesis of epileptic seizures. We used optogenetically induced model of hippocampal seizures. Multi-contact local field potentials were recorded during induction of hippocampal seizures and the information flow was analyzed statistically. Granger causality analysis revealed importance of information flow along longitudinal hippocampal axis during genesis of epileptic seizures.
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