| Project/Area Number |
23659682
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUNAYAMA Jun 山形大学, 医学部, 助教 (80466606)
SATO Atsushi 山形大学, 医学部, 助教 (30455901)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | glioma-initiating cell / glioma initiating cell / oxidative / phosphorylation |
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| Research Abstract |
In this project, we investigated the effect of a mitochondrial respiration-promoting agent on glioma stem cells with the intention to test the working hypothesis that inhibited mitochondrial respiration accompanied by increased aerobic glycolysis (Warburg effect), which has been frequently observed in malignant gliomas, contributes to the maintenance of glioma stem cells. Our results showed that promotion of mitochondrial respiration caused loss of stemness of glioma stem cells, suggesting that Warburg effect plays a significant role in the maintenance of glioma stem cells and that Warburg effect may be a promising target for cancer stem cell-directed therapy.
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