| Project/Area Number |
23659686
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
DATE Isao 岡山大学, 医歯(薬)学総合研究科, 教授 (70236785)
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| Co-Investigator(Kenkyū-buntansha) |
KUROZUMI Kazuhiko 岡山大学, 岡山大学病院, 講師 (20509608)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIU Kenji 岡山大学, 岡山大学病院, 准教授 (40325105)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 脳血管障害学 / CCNファミリー / CYR61 / もやもや病 / 脳動脈瘤 / 脳動静脈奇形 / 動脈硬化 / 脳血管攣縮 |
|---|
| Research Abstract |
We study the expression levels of the secreted protein cysteine-rich angiogenic-inducer 16 (CYR61) in patients with cerebrovascular disease and aim to develop a therapeutic strategy for CYR61. We received a CYR61-expressing plasmid from collaborators and identified an effective shRNA against CYR61. In brain tumor patients, multivariate Cox analysis revealed that CYR61 was an independent prognostic factor of survival. Now, we are evaluating the expression levels of CYR61 in different models of cerebrovascular disease.
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