Novel molecular target for cerebrovascular disease: CYR61 as angiogenic inducer
| Project/Area Number |
23659686
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
DATE Isao 岡山大学, 医歯(薬)学総合研究科, 教授 (70236785)
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| Co-Investigator(Kenkyū-buntansha) |
KUROZUMI Kazuhiko 岡山大学, 岡山大学病院, 講師 (20509608)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIU Kenji 岡山大学, 岡山大学病院, 准教授 (40325105)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 脳血管障害学 / CCNファミリー / CYR61 / もやもや病 / 脳動脈瘤 / 脳動静脈奇形 / 動脈硬化 / 脳血管攣縮 |
|---|
| Research Abstract |
We study the expression levels of the secreted protein cysteine-rich angiogenic-inducer 16 (CYR61) in patients with cerebrovascular disease and aim to develop a therapeutic strategy for CYR61. We received a CYR61-expressing plasmid from collaborators and identified an effective shRNA against CYR61. In brain tumor patients, multivariate Cox analysis revealed that CYR61 was an independent prognostic factor of survival. Now, we are evaluating the expression levels of CYR61 in different models of cerebrovascular disease.
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Report
(4 results)
Research Products
(213 results)
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[Presentation] Induction of an angiogenec factor, CYR61, in oncolytic viral therapy for malignant gliomas2013
Author(s)
Kurozumi K, Ichikawa T, Fujii K, Shimazu Y, Onishi M, Ishida J, Chiocca EA, Kaur B, Date I
Organizer
第19回日本遺伝子治療学会年次学術集会(The 19th Annual Meeting of Japan Society of Gene Therapy)
Place of Presentation
岡山
Year and Date
2013-07-05
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[Presentation] Induction of an angiogenec factor, CYR61, in oncolytic viral therapy for malignant gliomas
Author(s)
Kurozumi K , Ichikawa T , Fujii K , Shimazu Y , Onishi M , Ishida J , Chiocca EA , Kaur B , Date I
Organizer
第19回日本遺伝子治療学会年次学術集会（The 19th Annual Meeting of Japan Society of Gene Therapy)
Place of Presentation
岡山
Related Report
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[Presentation] Cilengitide, integrin inhibitor, enhances anti-glioma efficacy of vasculostatin-expressing oncolytic virus
Author(s)
Shimazu Y , Fujii K , Kurozumi K , Ichikawa T , Onishi M, Ishida J , Chiocca EA, Kaur B , Date I
Organizer
XV WFNS World Congress of Neurosurgery (WFNS 2013)
Place of Presentation
Seoul, Korea
Related Report
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[Presentation] Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma
Author(s)
Ichikawa T , Onishi M , Kurozumi K), Maruo T , Fujii K , Ishida J , Shimazu Y, Oka T, Chiocca EA , Date I
Organizer
18th Annual Meeting of the Society for Neuro-Oncology
Place of Presentation
San Francisco, U.S.A.
Related Report
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[Presentation] Proteomic analysis of invasion - and angiogenesis - related proteins in malignant gliomas
Author(s)
Takahashi Y , Ichikawa T , Maruo T , Kurozumi K, Onishi M , Ouchida M , Fujii K , Shimazu Y , Oka T , Chiocca EA , Date I
Organizer
18th Annual Meeting of the Society for Neuro-Oncology
Place of Presentation
San Francisco, U.S.A.
Related Report
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[Presentation] Multimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models
Author(s)
Umakoshi M , Ichikawa T , Kurozumi K , Onishi M , Fujii K , Ishida J , Shimazu Y , Oka T , Chiocca EA , Kaur B , Date I
Organizer
18th Annual Meeting of the Society for Neuro-Oncology
Place of Presentation
San Francisco, U.S.A.
Related Report
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[Presentation] Analysis of combination therapy of the adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) and the integrin antagonist cilengitide
Author(s)
Shimazu Y , Kurozumi K , Ichikawa T , Fujii K , Onishi M , Ishida J , Oka T , Watanabe M , Nasu Y , Kumon H , Date I
Organizer
18th Annual Meeting of the Society for Neuro-Oncology
Place of Presentation
San Francisco, U.S.A.
Related Report
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