| Project/Area Number |
23659691
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO Koji 九州大学, 大学病院, 講師 (70444784)
NAKAMIZO Akira 九州大学, 医学(系)研究科(研究院), 講師 (80529800)
AMANO Toshiyuki 九州大学, 大学病院, 助教 (70448413)
HATA Nobuhiro 九州大学, 大学病院, 助教 (10596034)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳腫瘍 / 神経膠腫 / microRNA / エキソソーム / バイオマーカー |
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| Research Abstract |
We isolated exosomal microRNAs from culture medium of glioma cell and total serum of glioma patients. The expression of secreted microRNA in the culture medium is correlated the microRNA expression of cultured glioma cells. We also established brain tumor stem cells and mouse xenograht models. We successfully analyzed secreted microRNA expression in total serum of xenographt models. We compared microRNA expression and gene expression in primary glioma samples, and revealed that miR-128a and miR-504 are associated with mesenchymal gene expression.
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