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Analysis of signal transduction pathways in brain pericytes in ischemic stroke

Research Project

Project/Area Number 23659692
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionKyushu University

Principal Investigator

SASAKI Tomio  九州大学, 医学研究院, 教授 (10134561)

Co-Investigator(Kenkyū-buntansha) MIZOGUCHI Masahiro  九州大学, 大学病院, 講師 (50380621)
NAKAMIZO Akira  九州大学, 医学研究院, 講師 (80529800)
KIKKAWA Yuichiro  九州大学, 大学病院, 助教 (80423515)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脳血管障害 / 周皮細胞 / 細胞内シグナル
Research Abstract

It has been suggested recently that brain pericytes play various important roles in ischemic stroke, but its detail mechnism remains elusive. In our project, we demonstrated that PDGFRβsignaling in brain pericytes in peri-infarct area was enhanced by basic fibroblast growth factor(bFGF) and mediated cell growth, survival and production of neurotrophic factors.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] PDGF receptor βsignaling in pericytes following ischemic brain injury2012

    • Author(s)
      Arimura K, Ago T, Kamouchi M, Nakamura K, Ishitsuka K, Kuroda J, Sugimori H, Ooboshi H, Sasaki T, Kitazono T
    • Journal Title

      Curr Neurovasc Res

      Volume: 9(1) Pages: 1-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] PDGF receptor β signaling in pericytes following ischemic brain injury2012

    • Author(s)
      Koichi Arimura
    • Journal Title

      Current Neurovascular Research

      Volume: 9 Pages: 1-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDGF receptor β signaling in pericytes following ischemic brain injury.2012

    • Author(s)
      Koichi Arimura
    • Journal Title

      Current Neurovascular Research

      Volume: 9 Pages: 1-9

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Neuroprotective Role of Brain Pericytes through PDGFRss-Akt Signaling in Ischemic Stroke2012

    • Author(s)
      Arimura K, Ago T, Kamouchi M, Sugimori H, Kuroda J, Ishitsuka K, Sasaki T, Kitazono T
    • Organizer
      International Stroke Conference 2012
    • Place of Presentation
      New Orleans, LA, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Neuroprotective Roles of Brain Pericytes through PDGFRss-Akt Signaling in Ischemic Stroke2012

    • Author(s)
      Arimura K, Ago T, Kamouchi M, Sugimori H, Kuroda J, Ishitsuka K, Sasaki T, Kitazono T
    • Organizer
      American Heart Association Scientific Sessions 2012 (Best of AHA specialty conference)
    • Place of Presentation
      Los Angeles, CA, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳虚血におけるPDGF-Bシグナルを介したペリサイトの神経保護作用2012

    • Author(s)
      有村公一, 吾郷哲朗, 杉森宏, 黒田淳 哉, 鴨打正浩, 佐々木富男, 北園孝成
    • Organizer
      第37回日本脳卒中学会総会, 福岡国際会議場
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳虚血におけるPDGF-Bシグナルを介したペリサイトの神経保護作用2012

    • Author(s)
      有村公一
    • Organizer
      第37回日本脳卒中学会総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neuroprotective Roles Brain Pericytes through PDGFR β -Akt Signaling in Ischemic Stroke.2012

    • Author(s)
      Koichi Arimura
    • Organizer
      International Stroke Conference 2012
    • Place of Presentation
      New Orleans
    • Related Report
      2011 Research-status Report
  • [Presentation] くも膜下出血後のエンドセリンによる筋フィラメントのカルシウム感受性亢進の増強作用とその機序2012

    • Author(s)
      吉川雄一郎
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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