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Isolation and characterization of an N-linked oligosaccharide that is increased in primary central nervous system lymphoma tissue and cell lines.

Research Project

Project/Area Number 23659695
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

YAMANAKA RYUYA  京都府立医科大学, 医学部, 教授 (20323991)

Co-Investigator(Kenkyū-buntansha) IKEAKA Kazuhiro  自然科学研究機構, 生理学研究所, 教授 (00144527)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords中枢神経原発悪性リンパ腫 / 糖タンパク糖鎖 / 脳腫瘍 / 糖蛋白質糖鎖 / 分子標的療法
Research Abstract

We have isolated and characterized N-linked oligo-saccharides that are significantly increased in primary central nervous system lymphoma (PCNSL) tissue and cell lines. The structures of N-linked oligosaccharides present in 3 human normal brain tissues, 34 patients with PCNSL and 1 PCNSL cell lines were analyzed by partially automated technique for the isolation and fluorescent labeling of N-linked sugar chains from glycoproteins. Characterization of the sugar chains was achieved with the use of a combination of HPLC columns and a highly sensitive fluorescence detector at femtomole levels. By collecting peaks which accounted for 0.1% or more, twenty-one different oligosaccharide structures were characterized. The amount of specific structure for PCNSL is now under investigation. Oligo-saccharides in specimens may provide a novel marker and target for the diagnosis and treatment of PCNSL, respectively.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (47 results)

All 2014 2013 2012 2011 Other

All Journal Article (19 results) (of which Peer Reviewed: 9 results,  Open Access: 1 results) Presentation (10 results) Book (8 results) Remarks (2 results) Patent(Industrial Property Rights) (8 results)

  • [Journal Article] Non-deep-seated primary CNS lymphoma - therapeutic responses and a molecular signature2014

    • Author(s)
      Iwadate Y, Suganami A, Ikegami S, Shinozaki N, Matsutani T, Tamura Y, Saeki N, Yamanaka R
    • Journal Title

      J Neurooncol

      Volume: 117(2) Pages: 261-268

    • Related Report
      2013 Final Research Report
  • [Journal Article] Non-deep-seated primary CNS lymphoma – therapeutic responses and a molecular signature2014

    • Author(s)
      Iwadate Y, Suganami A, Ikegami S, Shinozaki N, Matsutani T, Tamura Y, Saeki N, Yamanaka R
    • Journal Title

      J Neurooncol

      Volume: 117 Issue: 2 Pages: 261-268

    • DOI

      10.1007/s11060-014-1379-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene expression signature-based prognostic risk score in patients with glioblastoma2013

    • Author(s)
      Kawaguchi A, Yajima N, Tsuchiya N, Homma J, Sano M, Natsumeda M, Takahashi H, Fujii Y, Kakuma T, Yamanaka R
    • Journal Title

      Cancer Sci

      Volume: 104(9) Pages: 1205-1210

    • Related Report
      2013 Final Research Report
  • [Journal Article] Phase II study of personalized peptide vaccination for refractory bone and soft tissue sarcoma patients2013

    • Author(s)
      Takahashi R, Ishibashi Y, Hiraoka K, Matsueda S, Kawano K, Kawahara A, Kage M, Ohshima K, Yamanaka R, Shichijo S, Shirouzu K, Itoh K, Sasada T
    • Journal Title

      Cancer Sci

      Volume: 104(10) Pages: 1285-1294

    • Related Report
      2013 Final Research Report
  • [Journal Article] Radiation-Induced Glioblastoma Following Radiotherapy for Pituitary Adenomas : Marked Response to Chemotherapy2013

    • Author(s)
      Kon T, Natsumeda M, Takahashi H, Taki T,Fujii Y, Yamanaka R
    • Journal Title

      J Neurol Neurophysiol

      Volume: 4 Pages: 155-155

    • Related Report
      2013 Final Research Report
  • [Journal Article] Gene expression signature-based prognostic risk score in patients with glioblastoma.2013

    • Author(s)
      Kawaguchi A, Yajima N, Tsuchiya N, Homma J, Sano M, Natsumeda M, Takahashi H, Fujii Y, Kakuma T, Yamanaka R
    • Journal Title

      Cancer Sci

      Volume: 104 Pages: 1205-1210

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of personalized peptide vaccination for refractory bone and soft tissue sarcoma patients.2013

    • Author(s)
      Takahashi R, Ishibashi Y, Hiraoka K, Matsueda S, Kawano K, Kawahara A, Kage M, Ohshima K, Yamanaka R, Shichijo S, Shirouzu K, Itoh K, Sasada T.
    • Journal Title

      Cancer Sci.

      Volume: 104 Issue: 10 Pages: 1285-1294

    • DOI

      10.1111/cas.12226

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation-Induced Glioblastoma Following Radiotherapy for Pituitary Adenomas: Marked Response to Chemotherapy.2013

    • Author(s)
      Kon T, Natsumeda M, Takahashi H, Taki T,Fujii Y, Yamanaka R
    • Journal Title

      J Neurol Neurophysiol

      Volume: 4 Issue: 03 Pages: 155-155

    • DOI

      10.4172/2155-9562.1000155

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and Validation of a Gene Expression Signature That Predicts Outcome in Malignant Glioma Patients2012

    • Author(s)
      Kawaguchi A, Yajima N, Komohara Y, Aoki H, Tsuchiya N, Homma J, Sano M, Natsumeda M, Uzuka T, Saitoh A, Takahashi H, Sakai Y, Takahashi H, Fujii Y, Kakuma T, Yamanaka R
    • Journal Title

      Int J Oncol

      Volume: 40(3) Pages: 721-730

    • Related Report
      2013 Final Research Report
  • [Journal Article] Gene expression signature-based prognostic risk score in patients with primary central nervous system lymphoma2012

    • Author(s)
      Kawaguchi A, Iwadate Y, Komohara Y, Sano M, Kajiwara K, Yajima N, Tsuchiya N, Homma J, Aoki H, Kobayashi T, Sakai Y, Hondoh H, Fujii Y, Kakuma T, Yamanaka R
    • Journal Title

      Clin Cancer Res

      Volume: 18(20) Pages: 5672-5681

    • Related Report
      2013 Final Research Report
  • [Journal Article] 分子標的薬-がんから他疾患までの治癒をめざして2012

    • Author(s)
      山中龍也, 楠本華織(中川和彦、西尾和人 編)
    • Journal Title

      脳腫瘍(日本臨床社,東京)

      Pages: 421-427

    • Related Report
      2013 Final Research Report
  • [Journal Article] Identification and Validation of a Gene Expression Signature That Predicts Outcome in Malignant Glioma Patients2012

    • Author(s)
      Kawaguchi A, Yamanaka R, 他
    • Journal Title

      Int J Oncol

      Volume: 40(3) Pages: 721-30

    • DOI

      10.3892/ijo.2011.1240

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gene expression signature-based prognostic risk score in patients with primary central nervous system lymphoma2012

    • Author(s)
      Kawaguchi A, Yamanaka R, 他
    • Journal Title

      Clin Cancer Res

      Volume: 18(20) Issue: 20 Pages: 5672-81

    • DOI

      10.1158/1078-0432.ccr-12-0596

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination2011

    • Author(s)
      Noguchi M, Mine T, Komatsu N, Suekane S, Moriya F, Matsuoka K, Yutani S, Shichijo S, Yamada A, Toh U, Kawano K, Azuma K, Uemura H, Okuno K, Matsumoto K, Yanagimoto H, Yamanaka R, Oka M, Todo S, Sasada T, Itoh K
    • Journal Title

      Cancer Biol Ther

      Volume: 10(12) Pages: 1266-1279

    • Related Report
      2013 Final Research Report
  • [Journal Article] M2 macrophage/microglial cells induce activation of stat3 in primary central nervous system lymphoma2011

    • Author(s)
      Komohara Y, Horlad H, Ohnishi K, Ohta K, Makino K, Hondo H, Yamanaka R, Kajiwara K, Saito T, Kuratsu J, Takeya M
    • Journal Title

      J Clin Exp Hematop

      Volume: 51(2) Pages: 93-99

    • NAID

      10030207599

    • Related Report
      2013 Final Research Report
  • [Journal Article] 外来化学療法センターにおける症状チエックシートの有用2011

    • Author(s)
      吉田直久,中村晃和,松田清美,菅谷和子,富田英津子,石川 剛,八木信明,古倉 聡,内藤裕二,山中龍也,谷脇雅史,吉川敏一,三木恒治
    • Journal Title

      Progress in Medicine

      Volume: 31(4) Pages: 1163-1168

    • Related Report
      2013 Final Research Report
  • [Journal Article] Characteristics of patients with brain metastases from lung cancer in a palliative care center.2011

    • Author(s)
      Yamanaka R, Koga H, Yamamoto Y, Yamada S, Sano T, Fukushige T
    • Journal Title

      Support Care Cancer

      Volume: 19(4) Pages: 467-73

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination.2011

    • Author(s)
      Noguchi M, Mine T, Yamanaka R, et al.
    • Journal Title

      Cancer Biol Ther

      Volume: 10(12) Pages: 1266-79

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] M2 macrophage/microglial cells induce activation of stat3 in primary central nervous system lymphoma.2011

    • Author(s)
      Komohara Y, Horlad H, Ohnishi K, Ohta K, Makino K, Hondo H, Yamanaka R, Kajiwara K, Saito T, Kuratsu J, Takeya M.
    • Journal Title

      J Clin Exp Hematop

      Volume: 51(2) Pages: 93-9

    • NAID

      10030207599

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 悪性星細胞腫瘍患者の予後予測方法の探索2013

    • Author(s)
      山中龍也、川口淳、藤井幸彦、角間辰行
    • Organizer
      第11回日本臨床腫瘍学会学術集会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 悪性星細胞腫瘍患者の予後予測方法の探索2013

    • Author(s)
      山中龍也、川口淳、藤井幸彦、角間辰行
    • Organizer
      第11回日本臨床腫瘍学会学術集会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性星細胞腫瘍の遺伝子発現プロファイルによる予後予測方の検討2013

    • Author(s)
      山中龍也、森吉英子、川口淳、藤井幸彦、角間辰行
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性神経膠腫患者の予後を予測する遺伝子群の探索2012

    • Author(s)
      山中龍也、川口淳、角間辰行、酒井ゆうこ、藤井幸彦
    • Organizer
      第10回日本臨床腫瘍学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 悪性神経膠腫患者の予後を予測する遺伝子群の探索2012

    • Author(s)
      山中龍也、楠本華織、川口淳、青木洋、藤井幸彦
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 悪性神経膠腫患者の予後を予測する遺伝子群の探索2012

    • Author(s)
      山中龍也、川口淳、角間辰行、酒井ゆうこ、藤井幸彦
    • Organizer
      第10回日本臨床腫瘍学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] 悪性神経膠腫患者の予後を予測する遺伝子群の探索2012

    • Author(s)
      山中龍也、楠本華織、川口淳、青木洋、藤井幸彦
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 下垂体腺腫に対する照射22年後にmeningioma,30年後にglioma を発症した1例2011

    • Author(s)
      近 貴志、山中龍也、棗田 学、藤井幸彦、高橋 均
    • Organizer
      第52回日本神経病理学会総会学術研究会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 下垂体腺腫に対する照射22年後にmeningioma,30年後にgliomaを発症した1例2011

    • Author(s)
      近 貴志、山中龍也、棗田 学、藤井幸彦、高橋 均
    • Organizer
      第52回日本神経病理学会総会学術研究会
    • Place of Presentation
      パルコ京都(京都市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳腫瘍の免疫アップデート2011

    • Author(s)
      山中龍也
    • Organizer
      脳腫瘍レビュー‘11(招待講演)
    • Place of Presentation
      経団連会館(東京都)
    • Related Report
      2011 Research-status Report
  • [Book] Primary Central Nervous System Lymphoma-Recent advance on clinical research, In Terry Lichtor (ed.), Brain Tumors2013

    • Author(s)
      Yamanaka R
    • Publisher
      INTECH
    • Related Report
      2013 Final Research Report
  • [Book] Brain Tumors.2013

    • Author(s)
      Yamanaka R
    • Total Pages
      999
    • Publisher
      INTECH
    • Related Report
      2012 Research-status Report
  • [Book] Dendritic cell vaccine, In Yamanaka R (ed.), Glioma : Immunotherapeutic approaches2012

    • Author(s)
      Yamanaka R, Kajiwara K
    • Publisher
      Landes Bioscience, Austin, Texas
    • Related Report
      2013 Final Research Report
  • [Book] Glioma:Immunotherapeutic approaches.2012

    • Author(s)
      Yamanaka R, Kajiwara K
    • Total Pages
      232
    • Publisher
      Landes Bioscience/Springer
    • Related Report
      2012 Research-status Report
  • [Book] 分子標的薬―がんから他疾患までの治癒をめざして2012

    • Author(s)
      山中龍也, 楠本華織
    • Total Pages
      727
    • Publisher
      日本臨床社
    • Related Report
      2012 Research-status Report
  • [Book] Glioma: Immunotherapeutic approaches.2012

    • Author(s)
      Yamanaka R, Kajiwara K
    • Total Pages
      232
    • Publisher
      Landes Bioscience & Springer
    • Related Report
      2011 Research-status Report
  • [Book] Medical management of brain metastases from lung cancer, In Ana Lucia Abujamra(ed.), Brain Tumors / Current and emerging therapeutic strategies2011

    • Author(s)
      Yamanaka R
    • Publisher
      INTECH
    • Related Report
      2013 Final Research Report
  • [Book] Brain Tumors / Current and emerging therapeutic strategies.2011

    • Author(s)
      Yamanaka R
    • Total Pages
      422
    • Publisher
      INTECH
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.f.kpu-m.ac.jp/c/kouza/igaku/

    • Related Report
      2013 Final Research Report
  • [Remarks] 京都府立医科大学大学院保健看護学研究科医学講座

    • URL

      http://www.f.kpu-m.ac.jp/c/kouza/igaku/index.html

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 悪性神経膠腫Grade4 患者の予後予測方法及びキット2013

    • Inventor(s)
      山中龍也, 藤井幸彦, 角間辰之, 川口淳
    • Industrial Property Rights Holder
      新潟大学, 久留米大学, 京都府立医科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-06-13
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 悪性神経膠腫Grade4患者の予後予測方法及びキット2013

    • Inventor(s)
      山中龍也、藤井幸彦、角間辰之、川口淳
    • Industrial Property Rights Holder
      山中龍也、藤井幸彦、角間辰之、川口淳
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-124686
    • Filing Date
      2013-06-13
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] HLA-A24 分子結合性KIF 由来ペプチド2012

    • Inventor(s)
      伊東恭悟, 山中龍也, 原田守
    • Industrial Property Rights Holder
      新潟大学, 久留米大学
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2012-08-17
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 医薬組成物2012

    • Inventor(s)
      山中龍也, 土屋尚人, 池中一裕
    • Industrial Property Rights Holder
      新潟大学, 国立共同研究機構
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2012-12-21
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 中枢神経原発悪性リンパ腫患者の予後予測方法、キット及び使用2011

    • Inventor(s)
      山中龍也, 岩立康男, 藤井幸彦, 角間辰之, 川口淳, 梶原浩司
    • Industrial Property Rights Holder
      新潟大学, 千葉大学, 久留米大学, 山口大学, 京都府立医科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-07-13
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 脳腫瘍の検出方法及びそれに用いる脳腫瘍の検出物質2011

    • Inventor(s)
      山中龍也, 土屋尚人, 池中一裕
    • Industrial Property Rights Holder
      新潟大学, 国立共同研究機構
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2011-11-04
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 中枢神経原発悪性リンパ腫患者の予後予測方法.2011

    • Inventor(s)
      山中龍也、岩立康男、藤井幸彦、角間辰之、川口淳、梶原浩司
    • Industrial Property Rights Holder
      京都府立医科大学、千葉大学、新潟大学、久留米大学、山口大学
    • Industrial Property Number
      2011-154664
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 脳腫瘍の検出方法及びそれに用いる脳腫瘍の検出物質2011

    • Inventor(s)
      山中龍也、土屋尚人、池中一裕
    • Industrial Property Rights Holder
      新潟大学、自然科学研究機構
    • Filing Date
      2011
    • Acquisition Date
      2011
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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