Effect of citrus components on the injured spinal cord
| Project/Area Number |
23659699
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Matsuyama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Mitsunari 松山大学, 薬学部, 准教授 (70311404)
OKUYAMA Satoshi 松山大学, 薬学部, 助教 (40550380)
AMAKURA Yoshiaki 松山大学, 薬学部, 教授 (50321857)
YOSHIDA Takashi 松山大学, 薬学部, 教授 (20025696)
YOSHIMURA Morio 松山大学, 薬学部, 助教 (80454891)
FURUKAWA Shoei 岐阜薬科大学, 薬学部, 教授 (90159129)
FUKUMITSU Hidemitsu 岐阜薬科大学, 薬学部, 准教授 (00308280)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ヘプタメトキシフラボン / 脊髄損傷モデル動物 / BBB スコア / 柑橘化合物 / オーラプテン / BBBスコア / Neuro2a細胞 / PC12細胞 / 脳虚血モデルマウス |
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| Research Abstract |
We investigated the effect of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), one of the Citrus polymethoxyflavone (PMF), on the injured spinal cord. HMF was i.p. injeceted immediately after the surgery once a day for 4 weeks. We successfully observed that HMF ameliorated the locomotive activity (assessed by BBB score), but BDNF expression (assessed by immune-histochemistry) was not induced by HMF in the spinal cord.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in mice.2012
Author(s)
Okuyama S, Shimada N, Kaji M, Morita M, Miyoshi K, Minami S, Amakura Y, Yoshimura M, Yoshida T, Watanabe S, Nakajima M, FurukawaY.
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Journal Title
Neurosci. Lett.
Volume: 528
Issue: 2
Pages: 190-195
DOI
Related Report
Peer Reviewed
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