A study on the transcriptional regulation of type II collagen and aggrecan
Project/Area Number |
23659713
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
SHINOMURA Tamayuki 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (70206118)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 軟骨 / コラーゲン / アグリカン / エンハンサー / 転写制御 / II型コラーゲン / II 型コラーゲン / 国際情報交流・USA |
Research Abstract |
Type II collagen and aggrecan which are the major components of cartilage occupy more than 50% of the tissue dry weight. In this study, the transcriptional mechanism that controls the high level expression of these two molecules in chondrocytes was analyzed. As a result, I found new enhancer elements that areresponsible for the regulation of each gene expression.
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Report
(3 results)
Research Products
(11 results)