| Project/Area Number |
23659714
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MORITA Sadao 東京医科歯科大学, 医歯学総合研究科, 准教授 (20202426)
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| Co-Investigator(Kenkyū-buntansha) |
ASO Yoshinori 東京医科歯科大学, 医歯学総合研究科, 寄付講座教員 (50345279)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEDA Shu 慶應義塾大学, 医学部, 特任准教授 (30376727)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 骨代謝 / 酸化ストレス / 活性酸素 / シグナル伝達機構 / 破骨細胞 |
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| Research Abstract |
We aimed to study the role of reactive oxygen species in bone metabolism by using osteoclast-specific PHGPX-deficient mice. These mice developed hypoplasia of auricle, increase in osteoclast differentiation.
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