Clarification of the crosstalk between bone and blood pressure control.
| Project/Area Number |
23659715
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OKAWA Athushi 東京医科歯科大学, 医歯学総合研究科, 教授 (30251507)
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| Co-Investigator(Kenkyū-buntansha) |
ASO Yoshinori 東京医科歯科大学, 医歯学総合研究科, 寄付講座教員 (50345279)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEDA Shu 慶應義塾大学, 医学部, 特任准教授 (30376727)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 骨代謝 / 血圧調節機構 / プロレニン受容体 / 破骨細胞 / 骨芽細胞 / 軟骨細胞 / 血圧調節 / 臓器間クロストーク |
|---|
| Research Abstract |
To address the role of Prorenin Receptor(PRR) in bone metabolism, bone-specific PRR-deficient mice were analyzed. These mice displayed significantly reduced bone mass, inhibition of bone formation and decrease in the expression of osteoblast markers.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Porous/dense composite hydroxyapatite for anterior cervical discectomy and fusion2013
Author(s)
Yoshii T, Yuasa M, Sotome S, Yamada T, Sakaki K, Hirai T, Taniyama T, Inose H, Kato T, Arai Y, Kawabata S, Tomizawa S, Enomoto M, Shinomiya K, Okawa A
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Journal Title
Spine (Phila Pa 1976)
Volume: 38(10)
Issue: 10
Pages: 833-40
DOI
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Peer Reviewed
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[Journal Article] Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice2012
Author(s)
Hirai T, Enomoto M, Machida A, Yamamoto M, Kuwahara H, Tajiri M, Hirai Y, Sotome S, Mizusawa H, Shinomiya K, Okawa A, Yokota T
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Journal Title
Hum Gene Ther Methods
Volume: 23(2)
Pages: 119-27
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Peer Reviewed
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[Journal Article] Hybrid grafting using bone marrow aspirate combined with porous β-tricalcium phosphate and trephine bone for lumbar posterolateral spinal fusion: a prospective, comparative study versus local bone grafting.2012
Author(s)
Yamada T, Yoshii T, Sotome S, Yuasa M, Kato T, Arai Y, Kawabata S, Tomizawa S, Sakaki K, Hirai T, Shinomiya K, Okawa A.
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Journal Title
Spine (Phila Pa 1976).
Volume: 37(3)
Pages: 174-179
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Peer Reviewed
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[Journal Article] Middle-term results of a prospective comparative study of anterior decompression with fusion and posterior decompression with laminoplasty for the treatment of cervical spondylotic myelopathy.2011
Author(s)
Hirai T, Okawa A, Arai Y, Takahashi M, Kawabata S, Kato T, Enomoto M, Tomizawa S, Sakai K, Torigoe I, Shinomiya K.
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Journal Title
Spine (Phila Pa 1976).
Volume: 36(23)
Pages: 1940-1974
Related Report
Peer Reviewed
