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Establishment of genetically modified mice for the analysis of tendon/ligament formation and regeneration

Research Project

Project/Area Number 23659718
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionKyoto University

Principal Investigator

SHUKUNAMI Chisa  京都大学, 再生医科学研究所, 准教授 (60303905)

Research Collaborator SUGIMOTO Yuki  京都大学, 再生医科学研究所, 研究生
SHIMAMURA Satoko  京都大学, 再生医科学研究所, 大学院・生
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsScleraxis / Tenomodulin / 腱 / 靱帯 / 運動器
Research Abstract

During mouse development, Scleraxis(Scx), a basic-helix-loop-helix transcription factor, is continuously expressed in the tendon/ligament cell lineage, but transiently expressed in chondroprogenitors near the prospective attachment sites of tendons/ligaments into the skeletal elements. Tenomodlin(Tnmd), a type II transmembrane glycoprotein, is expressed in mature tenocytes and ligamentocytes. In this study, we have successfully generated genetically modified mice expressing Cre-recombinaseor fluorescent reporter genes in the expression domains of Scxor Tnmdas valuable tools for the analysis of tendon/ligament formation and regeneration

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2013 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 6 results) Presentation (11 results) (of which Invited: 3 results) Remarks (2 results)

  • [Journal Article] Scx+/Sox9+ progenitors contribute to the establishment of the junction between tendon/ligament.2013

    • Author(s)
      Y.Sugimoto,A.Takimoto,H.Akiyama,R.Kist,G.Scherer,T.Nakamura,Y.HIraki,and C.Shukunami
    • Journal Title

      Development.

      Volume: 140 Issue: 11 Pages: 2280-2288

    • DOI

      10.1242/dev.096354

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腱・靭帯形成の制御メカニズム2013

    • Author(s)
      宿南知佐
    • Journal Title

      Pharama Medica

      Volume: 31 Pages: 43-46

    • Related Report
      2012 Final Research Report
  • [Journal Article] Generation and characterization of ScxCre transgenic mice.2013

    • Author(s)
      Y. Sugimoto, A. Takimoto, Y. Hiraki, C. Shukunami
    • Journal Title

      Genesis.

      Volume: 51 Issue: 4 Pages: 275-283

    • DOI

      10.1002/dvg.22372

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腱・靱帯形成の制御メカニズム2013

    • Author(s)
      宿南知佐
    • Journal Title

      Pharma Medica

      Volume: 31 Pages: 43-50

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Direct conversion of tenocytes into chondrocytes by Sox92012

    • Author(s)
      A.Takimoto,M.Oro,Y.Hiraki,and C.Shukunami
    • Journal Title

      Exp Cell Res

      Volume: 318 Pages: 1492-1507

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct conversion of teonocytes into chondrocytes by Sox92012

    • Author(s)
      Takimoto A, 他
    • Journal Title

      Exp Cell Res

      Volume: (in press) Issue: 13 Pages: 1492-1507

    • DOI

      10.1016/j.yexcr.2012.04.002

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腱の形成と再生-Tenomodulin2011

    • Author(s)
      宿南知佐
    • Journal Title

      臨床整形外科

      Volume: 46 Pages: 528-532

    • Related Report
      2012 Final Research Report
  • [Journal Article] Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis.2011

    • Author(s)
      P. Alberton, C. Popov, M. Pragert, J. Kohler, C. Shukunami, M. Schieker, and D. Docheva.
    • Journal Title

      Stem Cells Dev

      Volume: 21 Issue: 6 Pages: 846-858

    • DOI

      10.1089/scd.2011.0150

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential expression of tenomodulin and chondromodul in-1 at the insertion site of the tendon reflects a phenotypic transtion of the resident cells2010

    • Author(s)
      K.Yukata,Y Matsui,C. Shukunami,A Takimoto, N,Hirohashi, O.Ohtani,T.Kimura,Y.Hiraki,N.Yasui
    • Journal Title

      Tissue Cells

      Volume: 48 Pages: 116-120

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 腱・靭帯付着部形成におけるScx/Sox9陽性細胞の役割2012

    • Author(s)
      杉本由紀、滝本晶、秋山治彦、中村孝志、開祐司、宿南知佐
    • Organizer
      第15回骨・再生研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 矯正的歯の移動モデルを用いた歯根膜におけるScleraxisの機能解析2012

    • Author(s)
      川津正慶、宿南知佐、滝本晶、岩崎将也、清流正弘、池田悦子、山本照子
    • Organizer
      第17回日本矯正歯科学会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 腱・靭帯形成とその制御2012

    • Author(s)
      宿南知佐
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Scleraxisの発現とその制御2012

    • Author(s)
      滝本晶、宿南知佐、川津正慶、清流正弘、山本照子、開祐司
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 腱・靭帯の形成と再生2011

    • Author(s)
      宿南知佐
    • Organizer
      第26回に本整形外科学基礎学術集会
    • Place of Presentation
      群馬県民会館、群馬
    • Year and Date
      2011-10-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 腱・靭帯形成の制御2011

    • Author(s)
      宿南知佐
    • Organizer
      第18回プロテオグリカンフォーラム(招待講演)
    • Place of Presentation
      東京医科歯科大学、東京
    • Year and Date
      2011-02-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 腱・靱帯の形成と再生2011

    • Author(s)
      宿南 知佐
    • Organizer
      第26回日本整形外科学会基礎学術集会(招待講演)
    • Place of Presentation
      前橋 (群馬県民会館)
    • Related Report
      2011 Research-status Report
  • [Presentation] Scleraxisの発現とその制御

    • Author(s)
      滝本晶、宿南知佐、川津正慶、清流正広、山本照子、開祐司
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 腱・靱帯形成とその制御

    • Author(s)
      宿南知佐
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 矯正的歯の移動モデルを用いた歯根膜におけるScleraxisの機能解析

    • Author(s)
      川津正慶、宿南知佐、滝本晶、岩崎将也、清流正広、池田悦子、山本照子
    • Organizer
      第71回日本矯正歯科学会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腱・靭帯付着部形成におけるScx/Sox9陽性細胞の役割

    • Author(s)
      杉本由紀, 滝本晶, 秋山治彦, 中村孝志, 開祐司, 宿南知佐
    • Organizer
      第15回骨発生・再生研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] 研究室のホームページ

    • URL

      http://www.frontier.kyoto-u.ac.jp/te01/index-j.htm

    • Related Report
      2012 Final Research Report
  • [Remarks] 発表論文(8)に関連して、Stem Cells&Regeneration from Development の Image Galleryに取り上げられた画像が納められているホームページ

    • URL

      http://stemcells.dev.biologists.org/page/image-gallery

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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