Analysis for the mechanism of the repair from injury of bone, cartilage and ligament using fluid microRNAs
| Project/Area Number |
23659719
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Hiromu 京都大学, 医学研究科, 准教授 (70397537)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マイクロRNA / 骨折治療 / バイオマーカー / 分泌マイクロRNA / 骨・軟骨・靭帯 |
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| Research Abstract |
We identified six microRNAs (miRs) that were significantly changed in the plasma of patients with a bone fracture compared to that of healthy volunteers (HVs). Among these, the plasma level of miR-D significantly decreased 24 h after the fracture. To investigate the possible involvement of miR-D in the bone repair, we administrated anti-miR-D nucleotides to the model mice of bone fractures. Callus formation and neovascularization were increased in the treated mice. This study demonstrated a new role of miRNAs in the process of bone repair and a possibility of an alternative treatment for bone fracture.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 17,000 assessments in the KURAMA database2013
Author(s)
Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, Yamakawa N, Yoshifuji H, Yukawa N, Kawabata D, Usui T, Yoshitomi H, Furu M, Yamada R, Matsuda F, Ito H, Fujii T, Mimori T
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Journal Title
PLoS One
Volume: 8(3)
Issue: 3
Pages: e59341-e59341
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.2012
Author(s)
Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.
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Journal Title
Arthritis Rheum
Volume: 64
Issue: 4
Pages: 1024-1034
DOI
Related Report
Peer Reviewed
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[Presentation] A crucial role for lectin-like oxidized LDL receptor-1 signal on cartilage destruction in inflammatory arthritis.2012
Author(s)
Ishikawa M,Ito H, Akiyoshi M, Yoshitomi H,Murata K, Tanida S, Shibuya H, Kume N, Sawamura T, Nakamura T
Organizer
58th Annual Meeting of the Orthopaedic Research Society
Place of Presentation
San Francisco, USA
Year and Date
2012-02-06
Related Report
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