Regeneration of growth plate using mesenchymal stem cells
| Project/Area Number |
23659721
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
YOSHIKAWA Hideki 大阪大学, 医学(系)研究科(研究院), 教授 (60191558)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Chikahisa 大阪大学, 保健センター, 助教 (40432421)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 成長軟骨帯損傷 / 骨橋 / 間葉系細胞 / 3次元人工組織 / 変形矯正 / 成長軟骨帯 / 成長軟骨帯再生 / 早期骨端線閉鎖 / 3次元間葉系細胞由来組織 / 早期成長軟骨帯閉鎖 |
|---|
| Research Abstract |
Growth plate injuries often cause bone shortening or angular deformities of affected bones because of total or partial bony bridging between epiphysis and metaphysis. In order to explore new method of the treatment of growth plate injuries, we investigated availability of 3-dimentional artificial tissue, which is made of synovium-derived mesenchymal stem cells, for the regeneration of injured growth plate. Our results demonstrated that physis-like cartilage tissue was reorganized by implantation of 3D tissue. Moreover, we confirmed that correction of bone shortening or angular deformities was followed after the regeneration of tissue regeneration.
|
Report
(4 results)
Research Products
(11 results)
