| Project/Area Number |
23659725
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Department of Clinical Research, National Hospital Organization Kure Medical Center |
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Principal Investigator |
MATSUO Toshihiro 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 医師 (90397977)
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| Co-Investigator(Kenkyū-buntansha) |
OCHI Mitsuo 広島大学, 大学院医歯薬保健学研究院, 教授 (70177244)
SHIMOSE Shoji 広島大学, 大学院医歯薬保健学研究院, 准教授 (30304439)
NAKASA Tomoyuki 広島大学, 病院, 病院助教 (60467769)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 遺伝子 / 老化 |
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| Research Abstract |
The aim of this research was to develop new treatment method for osteoarthritis using novel delivery system of telomere-related antiaging factors (hTERT, p38 MAPK inhibitor and Sirtuin 1) by bubble liposomes and ultrasound exposure. Bubble liposomes could not be prepared successfully by our method, therefore, we planned to introduce telomere-related microRNA in the chondrocyte in order to examine the antiaging effects. We measured the telomere length of rat chondrocyte by flow cytometer.
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