| Project/Area Number |
23659729
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMITSU Hidefumi 岐阜薬科大学, 薬学部, 准教授 (00308280)
SOUMIYA Hitomi 岐阜薬科大学, 薬学部, 助教 (20548713)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脊髄損傷 / 軸索再生 / 運動機能回復 / 脊髄由来間質系幹細胞 / FIF細胞 / 細胞移植 / 運動機能 / 歯髄細胞 / 間葉系幹細胞 |
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| Research Abstract |
In previous study, we have shown that the locomotor functions of the rats are improved after complete transection of the spinal cord, when FGF-2is directly injected into the spinal cord immediately after transection. A massive tissue composed of FGF-2-induced fibronectin-positive cells (FIFs) had appeared and filled large cystic cavities, into which numerous axons penetrated and through which they coursed. In this study, we have examined the possible existence of FIF-like cells in the primate tissues. We found that the transplantation of human dental pulp cells but not those of FIF-like cells derived from monkey spinal cord improved the locomotor functions of the rats after complete transection of the spinal cord.
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