| Project/Area Number |
23659732
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHTE Satoshi 埼玉医科大学, 医学部, 助教 (00547979)
SASANUMA Hiroki 埼玉医科大学, 医学部, 研究員 (30571707)
YONEYAMA Katsumi 埼玉医科大学, 医学部, 助手 (20571574)
SHIN Masashi 埼玉医科大学, 医学部, 研究員 (70549261)
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 遺伝子 / 転写 / 細胞・組織 / 骨形成 |
|---|
| Research Abstract |
We analyzed Bone morphogenetic protein(BMP)-responsive element(BRE) in the Id2 and Id3 genes. They had homologous BREs containing a 6 bp core sequence. The core sequence was essential for both the BMP-response and recognition by Smads. Co-transfection of Smad1 and Smad4 induced the reporter activity. These findings suggest that BMP signaling induces transcription of the Id genes through binding of Smads to the core sequences in the BREs.
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