A novel model for connecting growth and differentiation
| Project/Area Number |
23659732
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHTE Satoshi 埼玉医科大学, 医学部, 助教 (00547979)
SASANUMA Hiroki 埼玉医科大学, 医学部, 研究員 (30571707)
YONEYAMA Katsumi 埼玉医科大学, 医学部, 助手 (20571574)
SHIN Masashi 埼玉医科大学, 医学部, 研究員 (70549261)
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 遺伝子 / 転写 / 細胞・組織 / 骨形成 |
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| Research Abstract |
We analyzed Bone morphogenetic protein(BMP)-responsive element(BRE) in the Id2 and Id3 genes. They had homologous BREs containing a 6 bp core sequence. The core sequence was essential for both the BMP-response and recognition by Smads. Co-transfection of Smad1 and Smad4 induced the reporter activity. These findings suggest that BMP signaling induces transcription of the Id genes through binding of Smads to the core sequences in the BREs.
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Report
(2 results)
Research Products
(57 results)
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[Journal Article] Accumulation of p100, a precursor of NF-・B2, enhances osteoblastic differentiation in vitro and bone formation in vivo in aly/aly mice2012
Author(s)
Seo Y, Fukushima H, Maruyama T, Kurikoshi K, Osawa K, Nagano K, Aoki K, Weih F, Doi T, Zhang M, Ohya K, Katagiri T, Hosokawa R, and Jimi E.
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Journal Title
Mol Endocrinol
Volume: 26
Pages: 414-422
Related Report
Peer Reviewed
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[Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling2011
Author(s)
Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, Natsume T, and Katagiri T
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Journal Title
J Cell Biochem
Volume: 113
Pages: 808-814
Related Report
Peer Reviewed
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[Presentation] 筋の中に骨ができる2011
Author(s)
片桐岳信
Organizer
第1回彩の国骨フォーラム
Place of Presentation
埼玉県入間郡毛呂山町(招待講演)
Year and Date
2011-06-30
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