| Project/Area Number |
23659735
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hirosaki University |
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Principal Investigator |
UENO Shinya 弘前大学, 医学(系)研究科(研究院), 教授 (00312158)
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| Co-Investigator(Kenkyū-buntansha) |
NIKAIDO Yoshikazu 弘前大学, 医学(系)研究科(研究院), 助教 (50613478)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUZAWA Masashi 弘前大学, 農学生命科学部, 教授 (10231557)
YAMADA Junko 弘前大学, 医学(系)研究科(研究院), 講師 (30334965)
MIGITA Keisuke 弘前大学, 医学(系)研究科(研究院), 助教 (10352262)
TOMIYAMA Masahiko 弘前大学, 医学(系)研究科(研究院), 客員研究員 (40311542)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経科学 / 薬理学 / 情報伝達 / 麻酔薬作用機序 / タンパク輸送 / 麻酔薬 / GABA-A受容体 / 受容体トラフィッキング / リン酸化 / tonic inhibition / 麻酔薬作用 / 受容体trafficking / tonic GABA response |
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| Research Abstract |
Phospholipase C related, but catalytically inactive protein-1 (PRIP-1) plays a critical role in trafficking and phosphorylation of GABA-A receptor. We found that PRIP-1 KO mice showed abnormal distribution of GABA-A receptor, and that efficacy of general anesthetics in KO mice reduced in comparison to wild type. These results suggest that receptor trafficking is involved in the regulation of anesthetic action.
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