Research of novel regulatory mechanism of general anesthetics through receptor trafficking
| Project/Area Number |
23659735
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hirosaki University |
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Principal Investigator |
UENO Shinya 弘前大学, 医学(系)研究科(研究院), 教授 (00312158)
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| Co-Investigator(Kenkyū-buntansha) |
NIKAIDO Yoshikazu 弘前大学, 医学(系)研究科(研究院), 助教 (50613478)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUZAWA Masashi 弘前大学, 農学生命科学部, 教授 (10231557)
YAMADA Junko 弘前大学, 医学(系)研究科(研究院), 講師 (30334965)
MIGITA Keisuke 弘前大学, 医学(系)研究科(研究院), 助教 (10352262)
TOMIYAMA Masahiko 弘前大学, 医学(系)研究科(研究院), 客員研究員 (40311542)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経科学 / 薬理学 / 情報伝達 / 麻酔薬作用機序 / タンパク輸送 / 麻酔薬 / GABA-A受容体 / 受容体トラフィッキング / リン酸化 / tonic inhibition / 麻酔薬作用 / 受容体trafficking / tonic GABA response |
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| Research Abstract |
Phospholipase C related, but catalytically inactive protein-1 (PRIP-1) plays a critical role in trafficking and phosphorylation of GABA-A receptor. We found that PRIP-1 KO mice showed abnormal distribution of GABA-A receptor, and that efficacy of general anesthetics in KO mice reduced in comparison to wild type. These results suggest that receptor trafficking is involved in the regulation of anesthetic action.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype.2012
Author(s)
Zhu G, Yoshida S, Migita K, Yamada J, Mori F, Tomiyama M, Wakabayashi K, Kanematsu T, Hirata M, Kaneko S, Ueno S, Okada M.
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Journal Title
J Pharmacol Exp Ther
Volume: 340
Pages: 520-528
Related Report
Peer Reviewed
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