Effects of Highly-concentrated Inhalational anesthetic exposure during pregnancy on neurodegeneration of neonatal mice
| Project/Area Number |
23659744
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kobe University |
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Principal Investigator |
UOKWA Reiko 神戸大学, 医学研究科, 医学研究員 (50467651)
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| Co-Investigator(Kenkyū-buntansha) |
UEKI Masaaki 神戸大学, 大学院・医学研究科, 医学研究員 (20213332)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 吸入麻酔薬 / 妊娠 / 脳神経変性 / 未熟脳 / マウス / BDNF / ＧＡＢＡ受容体 / 麻酔薬 / 脳神経発達 |
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| Research Abstract |
Exposure of 2.9% isoflurane on pregnant mice (embryonic day 17) had an influence on learning function, morphological synapse formation (synaptophysin staining) and BDNF mRNA on postnatal day 7. Furthermore, exposure of 2.9% isoflurane on pregnant mice effected brain NKCC/KCC2mRNA ratio.
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Report
(3 results)
Research Products
(3 results)
