Ischemic heart protection strategy in cellular senescence and related conditions
| Project/Area Number |
23659746
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUIMKAWA Koji 長崎大学, 大学院・医歯薬学総合研究科, 教授 (60028660)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞老化 / 薬理学的心筋保護法 / 薬理学的心筋保護 / 心筋虚血再灌流障害 / 耐糖能異常 / 薬理学的ポストコンディショニング |
|---|
| Research Abstract |
Pharmacological post-conditioning against myocardial infarction is discovered to be preserved the effect under hyperglycemia, one of the pathologic condition associated with the cellular senescence. Milrinone was not affected by hyperglycemia, and hyperglycemia raises the threshold of levosimendan and fasudil-induced postconditioning.
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Report
(3 results)
Research Products
(6 results)
