Ischemic heart protection strategy in cellular senescence and related conditions

• Project/Area Number: 23659746
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagasaki University
• Principal Investigator: SUIMKAWA Koji 長崎大学, 大学院・医歯薬学総合研究科, 教授 (60028660)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 細胞老化 / 薬理学的心筋保護法 / 薬理学的心筋保護 / 心筋虚血再灌流障害 / 耐糖能異常 / 薬理学的ポストコンディショニング

Research Abstract

Pharmacological post-conditioning against myocardial infarction is discovered to be preserved the effect under hyperglycemia, one of the pathologic condition associated with the cellular senescence. Milrinone was not affected by hyperglycemia, and hyperglycemia raises the threshold of levosimendan and fasudil-induced postconditioning.

Research Products

• [Journal Article] Hyperglycemia raises the threshold of levosimendan-but not milrinone-induced postconditioning in rat hearts (2012)
  • Author(s): 松本周平, 趙成三, 戸坂真也, 東島潮, 前川拓治, 原哲也, 澄川耕二
  • Journal Title: Cardiovascular Diabetology Volume: 11:4 Issue: 1 Pages: 4-4
  • DOI: 10.1186/1475-2840-11-4
  • Peer Reviewed
• [Journal Article] High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels (2012)
  • Author(s): Taiga Ichinomiya, Sungsam Cho, Ushio Higashijima, Shuhei Matsumoto, Takuji Maekawa, Koji Sumikawa
  • Journal Title: Cardiovasc Diabetol Volume: 11(1) Issue: 1 Pages: 28-28
  • DOI: 10.1186/1475-2840-11-28
  • NAID: 120006985422
  • Peer Reviewed
• [Presentation] Interaction of remort ischemic preconditioning with anesthetics in rat hearts (2012)
  • Author(s): Shuhei Matsumoto、Koji Sumikawa、et al
  • Organizer: Anesthesiology
  • Place of Presentation: アメリカ
  • Year and Date: 2012-10-16
• [Presentation] High-dose fasudil preservespostconditioning against myocardial infarction under hyperglycemia inrats:role of mitochondrial KATP channels (2012)
  • Author(s): Koji Sumikawa、Taiga Ichinomiya、et al
  • Organizer: World Congress of Anesthesiologists
  • Place of Presentation: トルコ
  • Year and Date: 2012-04-22
• [Presentation] Interaction of remort ischemic preconditioning with anesthetics in rat hearts. (2012)
  • Author(s): Shuhei Matsumoto
  • Organizer: Anesthesiology
  • Place of Presentation: Washinton
• [Presentation] High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats:role of mitochondrial KATP channels (2012)
  • Author(s): Koji Sumikawa
  • Organizer: World Congress of Anesthesiologists
  • Place of Presentation: Istanbul