International study for therapeutic hypothermia by drug induced/focal brain cooling against peri-operative stroke

• Project/Area Number: 23659751
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kurume University
• Principal Investigator: KYOKO Abe 久留米大学, 医学部, 助教 (50569522)
• Co-Investigator(Kenkyū-buntansha): HARADA Hideki 久留米大学, 医学部, 准教授 (30198923)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 脳保護 / 薬剤導入性低体温 / 局所脳冷却 / 国際共同研究 / 国際情報交換 / 国際研究者交流 / 脳虚血 / ドイツ / 脳虚血障害 / 長期低体温療法 / 薬剤誘発 / 局所冷却

Research Abstract

Therapeutic hypothermia after cerebral ischemic insult is one of the most potent neuroprotective strategies, even with some complications. An ideal approach for hypothermia induction is the usage of pharmacological compounds. We investigated the transient receptor potential vanilloid-1 (TRPV1), as a potential target for drug-induced hypothermia. We identified that TRPV1 agonist leads to a significant decrease in brain and body temperature. Both temperatures remained within the optimal range for therapeutic hypothermia for 2h. In the second part of our study we examined an approach for focal brain cooling using a Peltier device. The device was able to reduce intracranial temperature and was maintained constant for 2h without altering body temperature. To analyze its neuroprotective effect, we used the permanent and transient focal cerebral ischemia and examined the infarction volume after short and long period of focal brain cooling, showing protective effects in both models.

Research Products

• [Presentation] Two approaches for therapeutic hypothermia induction after ischemic brain injury : TRPV1-agonist-induced pharmacologic hypothermia and Peltier-deviceinduced focal brain cooling (2013)
  • Author(s): María Mercedes Tejada Bonilla, Hideki Harada, Kazuo Ushijima, Stefan Schwab, Rainer Kollmar, and Miyuki Tauchi
  • Organizer: 43^<rd> Annual meeting Neuroscience
  • Place of Presentation: San Diego, United States
• [Presentation] The role of TRPV1 receptor against Acute ischemic Stroke with pharmacologically induced cerebral ischemia in rats (2013)
  • Author(s): María Mercedes Tejada Bonilla, Hideki Harada, Kazuo Ushijima, Stefan Schwab, Rainer Kollmar, and Miyuki Tauchi
  • Organizer: 日本麻酔科学会第60回学術集会
  • Place of Presentation: 札幌、日本
• [Presentation] Two approaches for therapeutic hypeothermia induction after ischemic brain injury:TRPV1-agonist-induced focal brain cooling (2013)
  • Author(s): Tejada Bonilla M, Harada H, Ushijima K, Tauchi M
  • Organizer: 43rd Annual Meeting Neuroscience 2013
  • Place of Presentation: サンディエゴ
• [Presentation] The Role of TRPV1 Receptor against Acute Ischemic Stroke with pharmacologically induced cerebral hypothermia in rats (2013)
  • Author(s): Tejada Bonilla Maria Mercedes,Harada Hideki,Ushijima Kazuo,Schwab Stefan,Kollmar Rainer,Tauchi Miyuki
  • Organizer: 日本麻酔科学会第６０回学術集会
  • Place of Presentation: 札幌