| Project/Area Number |
23659753
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
IGARASHI Tatsuo 千葉大学, フロンティア医工学センター, 教授 (70302544)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YU Wenwei 千葉大学, フロンティア医工学センター, 教授 (20312390)
RYU Hiroshi 千葉大学, 大学院工学研究科, 教授 (40303698)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 排尿生理学 / 数値流体力学 / シミュレーション / 立体画像 / 内視鏡 / 内視鏡画像 / 仮想内視鏡 / 尿流動態 / 尿道機能 / 細径内視鏡 / スエーデン / 国際情報交流 / イスラエル / 米国 / オランダ |
|---|
| Research Abstract |
Relationship between deformation of the male prostatic urethra and alteration of urine flow in the urethra was studied using computational flow dynamics (CFD). Since estimation of elasticity of urethral wall by assessing its vibration under irrigation had failed during the study period, urine flow simulation was performed using the solid model of the urethra. Calculation using bladder outlet (BO) obstruction model revealed size of the BO directly altered dynamics and energy loss of urine flow in the prostatic urethra. Energy loss of the urine flow was studied using 3D virtual prostatic urethra processed from endoscopic video image in patients with benign prostate hyperplasia around administration of alpha-1 adrenoceptor antagonists. The energy loss, provoked by deformation of urethra, revealed to correlate with some parameters of voiding function. The study showed usefulness of CFD in assessing urethral function in patients with voiding dysfunction.
|
