Mechanisms And Possible Novel Treatments for Nocturiarelated to Abnormal Circadian Rhythm
| Project/Area Number |
23659754
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
TAKEDA Masayuki 山梨大学, 大学院・医学工学総合研究部, 教授 (80197318)
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| Co-Investigator(Kenkyū-buntansha) |
ZAKOJI Hidenori 山梨大学, 大学院・医学工学総合研究部, 助教 (60345717)
NAKAGOMI Hiroshi 山梨大学, 医学部附属病院, 助教 (80418714)
SAWADA Norifumi 山梨大学, 医学部附属病院, 助教 (70402055)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 時計遺伝子 / 過活動膀胱 / 夜間頻尿 / 機械受容体 / VNUT / ATP / Piezo1 / メカノセンサー / 膀胱 / 尿路上皮 |
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| Research Abstract |
Some of TRP (Transient Receptor Potential)s is thought to be important as mechano-sensitive cation channels in the urinary bladder. Afteractivation of TRPV4 by stretch, ATP is released from the urothelial cells. The mechanisms of ATP production by cell-stretch include a novel small molecule transporter VNUT (Vesicular nucleotide transporter), and the expression level of VNUT correlates with human bladder function. Piezo 1, a novel mechanosensor molecule, is important for urinary bladder function. Knockout mice of Per 2, a clock gene, show disappearance of circadian rhythm.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Fesoterodine, its active metabolite and tolterodine bind selectively to muscarinic receptors in human bladder mucosa and detrusor muscle2013
Author(s)
Akira Yoshida, Yusuke Fuchihata , Shiori Kuraoka , Ayaka Osano , Atsushi Otsuka , Seiichiro Ozono , Masayuki Takeda, Keisuke Masuyama ,Isao Araki , Shizuo Yamada
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Decreased Expression of the Epithelial Ca2+ Channel TRPV5 and TRPV6 in Human Renal Cell Carcinoma: Associated with Vitamin D Receptor2011
Author(s)
Yongyang Wu, Tatsuya Miyamoto, Kai Li, Hiroshi Nakagomi, Norifumi Sawada, Satoru Kira, Hideki Kobayashi, Hidenori Zakoji, Takayuki Tsuchida, Mizuya Fukazawa, Isao Araki, Masayuki Takeda
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Journal Title
J. Urol
Volume: 186
Pages: 2419-2425
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Peer Reviewed
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[Presentation] Significant correlation between Vitamine D receptor and epithelial Ca2+ ion channel TRPV5 and TRPV6 in renal cell carcinoma2012
Author(s)
Wu Yongyang, Tatsuya Miyamoto , Li Kai , Hiroshi Nakagomi, Norifumi Sawada, Satoru Kira, Hideki Kobayashi , Hidenori Zakoji, Isao Araki , Masayuki Takeda
Organizer
The 107th Annual Meeting of The American Urological Association
Place of Presentation
Atlanta, USA
Year and Date
2012-05-20
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[Book] Health Publication Ltd2013
Author(s)
Fry CH, Chako S, Wacher S.de, Kanai AJ, Takeda M, Young JS
Publisher
Abrams, P., Cardozo, L., Khoury, S., Wein, A. ed
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