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Mechanisms And Possible Novel Treatments for Nocturiarelated to Abnormal Circadian Rhythm

Research Project

Project/Area Number 23659754
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionUniversity of Yamanashi

Principal Investigator

TAKEDA Masayuki  山梨大学, 大学院・医学工学総合研究部, 教授 (80197318)

Co-Investigator(Kenkyū-buntansha) ZAKOJI Hidenori  山梨大学, 大学院・医学工学総合研究部, 助教 (60345717)
NAKAGOMI Hiroshi  山梨大学, 医学部附属病院, 助教 (80418714)
SAWADA Norifumi  山梨大学, 医学部附属病院, 助教 (70402055)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords時計遺伝子 / 過活動膀胱 / 夜間頻尿 / 機械受容体 / VNUT / ATP / Piezo1 / メカノセンサー / 膀胱 / 尿路上皮
Research Abstract

Some of TRP (Transient Receptor Potential)s is thought to be important as mechano-sensitive cation channels in the urinary bladder. Afteractivation of TRPV4 by stretch, ATP is released from the urothelial cells. The mechanisms of ATP production by cell-stretch include a novel small molecule transporter VNUT (Vesicular nucleotide transporter), and the expression level of VNUT correlates with human bladder function. Piezo 1, a novel mechanosensor molecule, is important for urinary bladder function. Knockout mice of Per 2, a clock gene, show disappearance of circadian rhythm.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (7 results) (of which Invited: 1 results) Book (5 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Fesoterodine, its active metabolite and tolterodine bind selectively to muscarinic receptors in human bladder mucosa and detrusor muscle2013

    • Author(s)
      Akira Yoshida, Yusuke Fuchihata , Shiori Kuraoka , Ayaka Osano , Atsushi Otsuka , Seiichiro Ozono , Masayuki Takeda, Keisuke Masuyama ,Isao Araki , Shizuo Yamada
    • Journal Title

      Urology

      Volume: 81

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Urethane on reflex activity of lower urinary tract in decerebrate unanesthetized rats2013

    • Author(s)
      Mitsuharu Yoshiyama , Roppolo James R , Masayuki Takeda , William C de Groat
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 304

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Connexin 43 hemichannel-mediated regulation of connexin 432013

    • Author(s)
      Kai Li ,Yuan Chi, Qiaojian Yan, Kun Gao ,Hiroyuki Matsue , Masayuki Takeda, Masanori Kitamura, Jian Yao
    • Journal Title

      PLoS One

      Volume: 88:e58057

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beta-Catenin-Signaling Contributes to Platelet Derived Growth Factor Elicited Bladder Smooth Muscle Cell Contraction Through Up-Regulation of Cx43 Expression2012

    • Author(s)
      Kai Li, Jian Yao, Norifumi Sawada, Masanori Kitamura, Kar-Eric Andersson, Masayuki Takeda
    • Journal Title

      J Urol

      Volume: 188 Pages: 306-315

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tadalafil for the Treatment of Lower Urinary Tract Symptoms in Japanese Men with Benign Prostatic Hyperplasia2012

    • Author(s)
      Masayuki Takeda, Osamu Nishizawa , Takeshi Imaoka, Yoji Morisaki, Lars Viktrup
    • Journal Title

      Results from a 12-week Placebo-controlled Dose-finding Study with a 42-week Open-label Extension

      Volume: 4 Pages: 110-119

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] β-catenin signaling contributes to PDGF-elicited bladder smooth muscle cell contraction through up-regulation of Cx43 expression2012

    • Author(s)
      Li K, Yao J, Sawada N, Kitamura M, Andersson K-E, and Takeda M
    • Journal Title

      J Urol

      Volume: 188 Issue: 1 Pages: 307-332

    • DOI

      10.1016/j.juro.2012.02.2556

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal regulation between proinflammatory cytokine- induced iNOS and connexin43 in bladder smooth muscle cells2011

    • Author(s)
      Kai Li, Jian Yao, Liye Shi, Norifumi Sawada, Yuan Chi, Qiaojing Yan, Hiroyuki Matsue, Masanori Kitamura, Masayuki Takeda
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 41552-41562

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased Expression of the Epithelial Ca2+ Channel TRPV5 and TRPV6 in Human Renal Cell Carcinoma: Associated with Vitamin D Receptor2011

    • Author(s)
      Yongyang Wu, Tatsuya Miyamoto, Kai Li, Hiroshi Nakagomi, Norifumi Sawada, Satoru Kira, Hideki Kobayashi, Hidenori Zakoji, Takayuki Tsuchida, Mizuya Fukazawa, Isao Araki, Masayuki Takeda
    • Journal Title

      J. Urol

      Volume: 186 Pages: 2419-2425

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bladder Outlet Obstruction-Induced Expression of Prostaglandin E2 Receptor Subtype EP4 in the Rat Urinary Bladder: a Possible Counteractive Mechanism Against Detrusor Overactivity2011

    • Author(s)
      Masanori Beppu , Isao Araki, Mitsuharu Yoshiyama ,Shuqi Du, Hideki Kobayashi , Hidenori Zakoji, Masayuki Takeda
    • Journal Title

      J. Urol

      Volume: 186 Pages: 2463-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bladder outlet obstruction induced expression2011

    • Author(s)
      Masanori Beppu
    • Journal Title

      Journal of Urology

      Volume: 186 Pages: 2463-2469

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] AUA Plenary Session 3. Highlight on Urodynamics/Female Urology2012

    • Author(s)
      Masayuki Takeda
    • Organizer
      The 107th Annual Meeting of The American Urological Association
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2012-05-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of increased voiding frequency in mice with type 2 diabetes mellitus2012

    • Author(s)
      Mitsuharu Yoshiyama, Tsutomu Mochizuki , Hiroshi Nakagomi, Tatsuya Miyamoto, Masayuki Takeda
    • Organizer
      The 107th Annual Meeting of The American Urological Association
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2012-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Beta-catenin signaling PDGF-elicited bladder smooth muscle cell contraction through upregulation of Cx43 expression2012

    • Author(s)
      Li Kai, Jian Yao , Norifumi Sawada, Tatsuya Miyamoto, Masanori Kitamura, Masayuki Takeda
    • Organizer
      The 107th Annual Meeting of The American Urological Association
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2012-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] VNUT(Vesivularnucleotide transporter) plays a crucial role in atretch-evoked ATP release from the urothelium2012

    • Author(s)
      Hiroshi Nakagomi, Tsutomu Mochizuki , Tatsuya Miyamoto, Mitsuharu Yoshiyama , Isao Araki, Yoshinori Moriyama, Schuichi Koizumi, Masayuki Takeda
    • Organizer
      The 107th Annual Meeting of The American Urological Association
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2012-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Significant correlation between Vitamine D receptor and epithelial Ca2+ ion channel TRPV5 and TRPV6 in renal cell carcinoma2012

    • Author(s)
      Wu Yongyang, Tatsuya Miyamoto , Li Kai , Hiroshi Nakagomi, Norifumi Sawada, Satoru Kira, Hideki Kobayashi , Hidenori Zakoji, Isao Araki , Masayuki Takeda
    • Organizer
      The 107th Annual Meeting of The American Urological Association
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2012-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] NfKAPPAB/INOS/CAMP SIGNALING CASCADE MEDIATES2011

    • Author(s)
      Kai Li
    • Organizer
      AUA Annual Meeting 2011(招待講演)
    • Place of Presentation
      convention center(Washington D.C.)
    • Related Report
      2011 Research-status Report
  • [Presentation] NfKAPPAB/INOS/CAMPSIGNALINGCASCADEMEDIATES

    • Author(s)
      KaiLi,JianYao,NorifumiSawada
    • Organizer
      AUAAnnualMeeting2012
    • Place of Presentation
      Georgia World Congress Center(Atlanta USA)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Health Publication Ltd2013

    • Author(s)
      Fry CH, Chako S, Wacher S.de, Kanai AJ, Takeda M, Young JS
    • Publisher
      Abrams, P., Cardozo, L., Khoury, S., Wein, A. ed
    • Related Report
      2012 Final Research Report
  • [Book] 排尿・蓄尿障害(尿閉,残尿感,尿失禁)腎疾患治療マニュアル2012

    • Author(s)
      武田正之
    • Publisher
      東京医学社
    • Related Report
      2012 Final Research Report
  • [Book] 各論 第4 章尿路疾患(泌尿器科関連疾患)2012

    • Author(s)
      武田正之
    • Publisher
      診断と治療社
    • Related Report
      2012 Final Research Report
  • [Book] 腎疾患治療マニュアル2012-132012

    • Author(s)
      武田正之
    • Publisher
      東京医学社
    • Related Report
      2012 Annual Research Report
  • [Book] メデイカルレビュー社2011

    • Author(s)
      武田正之
    • Total Pages
      952
    • Publisher
      ポケット版 治療薬update 2011
    • Related Report
      2011 Research-status Report
  • [Remarks] なし

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 新規頻尿治療薬としての GsMTX4 の 効果2012

    • Inventor(s)
      宮本達也
    • Industrial Property Rights Holder
      宮本達也
    • Filing Date
      2012-10-19
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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