| Project/Area Number |
23659756
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAMURA Masaaki 京都大学, 医学研究科, 助教 (20594237)
SHIMIZU Yousuke 京都大学, 医学研究科, 助教 (00542094)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 夜尿症 / 住民検診コホート / PTHrP / コホート / GWAS |
|---|
| Research Abstract |
Enuresis is considered to be related to genetic background, but no responsible gene was investigated. Then, we aimed to elucidate the responsible gene with reference to previous enuresis history in general populations. But, the genetic analysis had been significantly delayed, so we established an animal experimental model which reflects physiological mechanism of enuresis, and aimed to investigate the responsible gene of enuresis from this approach. As a result, we picked up the candidate gene “PTHrP” as a potent endogenous relaxant of bladder contraction.
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