The role of bone marrow-derived cells in the development of tumor vessels in renal cell carcinoma
| Project/Area Number |
23659757
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 腫瘍学 / 腎細胞癌 / 腫瘍血管 / EMMPRIN / 骨髄由来細胞 |
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| Research Abstract |
It is quite important to understand the nature of tumor vessels in the treatment of renal cell cancer (RCC). In this study, we found that EMMPRIN (extracellular matrixmetalloproteinase inducer), which enhances production of collagenase, have an important role in angiogenesis in RCC. Unfortunately, we were not able to clarify the role of bone marrow-derived endothelial progenitor cells (EPC) in the development of tumor vessels, however, it might be possible that in the microenvironment which is modified by expression of EMMPRIN by RCC, EPC plays some role in angiogenesis.
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Report
(3 results)
Research Products
(9 results)
