| Project/Area Number |
23659758
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Ken-ichi 京都府立医科大学, 大学院・医学研究科, 准教授 (40315932)
MIKI Tsuneharu 京都府立医科大学, 大学院・医学研究科, 教授 (10243239)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 泌尿器科学 / アンドロロジー / 男性性機能 / 勃起障害 / アンドロゲン / 中枢神経系 / ホルモン / 脊髄 / 神経 |
|---|
| Research Abstract |
We applied the high-voltage electron microscopy (HVEM) tomography assisted by light microscopy to a study of the 3-D chemical neuroanatomy of the rat lower spinal cord annotated by double-labeling immunohistochemistry. This powerful methodology is useful for studying molecular and/or chemical neuroanatomy at the 3-D ultrastructural level. The induction of phosphorylated extracellular signal-related kinase (pERK) is well accepted as a marker for neuronal activation. Consequently, we studied the expression of pERK in the gastrin-releasing peptide (GRP) neurons after ejaculation. This revealed that pERK induction in the GRP neurons appeared to be specifically associated with ejaculation, suggesting the activation of GRP neurons during male sexual behavior.
|
