Pathophysiology of psychogenic erectile dysfunction inthe central nervous system
Project/Area Number |
23659758
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Urology
|
Research Institution | Okayama University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MATSUDA Ken-ichi 京都府立医科大学, 大学院・医学研究科, 准教授 (40315932)
MIKI Tsuneharu 京都府立医科大学, 大学院・医学研究科, 教授 (10243239)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 泌尿器科学 / アンドロロジー / 男性性機能 / 勃起障害 / アンドロゲン / 中枢神経系 / ホルモン / 脊髄 / 神経 |
Research Abstract |
We applied the high-voltage electron microscopy (HVEM) tomography assisted by light microscopy to a study of the 3-D chemical neuroanatomy of the rat lower spinal cord annotated by double-labeling immunohistochemistry. This powerful methodology is useful for studying molecular and/or chemical neuroanatomy at the 3-D ultrastructural level. The induction of phosphorylated extracellular signal-related kinase (pERK) is well accepted as a marker for neuronal activation. Consequently, we studied the expression of pERK in the gastrin-releasing peptide (GRP) neurons after ejaculation. This revealed that pERK induction in the GRP neurons appeared to be specifically associated with ejaculation, suggesting the activation of GRP neurons during male sexual behavior.
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Report
(3 results)
Research Products
(58 results)
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[Journal Article] Bleeding from humeral head induces bone marrow-derived cells to repair tendons after rotator cuff repair2013
Author(s)
Y. Kida, T. Morihara, K. I. Matsuda, Y. Kajikawa, H. Tachiiri, Y. Iwata, K. Sawamura, A. Yoshida, Y. Oshima, H. Fujiwara, M. Kurokawa, M. Kawata, T. Kubo
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Journal Title
Journal of Shoulder and Elbow Surgery
Volume: 22
Issue: 2
Pages: 197-205
DOI
Related Report
Peer Reviewed
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[Journal Article] Visualization of oestrogen receptorα-positive neurons in transgenic mice expressing GFP under the control of the oestrogen receptor α promoter.2013
Author(s)
Matsuda, K., Yanagisawa, M., Sano, K., Ochiai, I., Musatov, S., Okoshi, K., Tsukahara, S., Ogawa, S., and Kawata, M.
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Journal Title
European Journal of Neuroscience
Volume: 38
Issue: 2
Pages: 2242-2249
DOI
Related Report
Peer Reviewed
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[Journal Article] Gelatin β-tricalcium phosphate sponge with platelet-rich plasma enhances bone regeneration in a massive bone defect of ulna2012
Author(s)
N. Yamada, W. C. Kim, T. Yoshida, Y. Oka, T. Ikeda, H. Fujiwara, A. Nishida, K. I.Matsuda, Y. Tabata, M. Kawata, T. Kubo
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Journal Title
Journal of Medical and Biological ngineering
Volume: (in press)
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