The clinical usefulness of a chemosensitivity assay using a new rimary culture system with spheroids on the bIadder cancer

Research Project

Project/Area Number	23659766
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Urology
Research Institution	Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
Principal Investigator	NAKAYAMA Masashi 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 泌尿器科, 副部長 (40379178)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	膀胱癌 / テーラーメイド医療
Research Abstract	The aim of the study is to show the clinical usefulness of a chemosensitivity assay using a new primary culture system with spheroids on the bladder cancer. On muscle-invasive bladder cancer, this chemosensitivity assay may predict the effect of systemic chemotherapy with cisplatin and gemcitabine. We tried to identify a marker to predict the effect of intravesical chemotherapy immediate after transurethral resection of the bladder cancer. However, we have not found it yet.