Progestogen prevents hypoxic-ischemic encephalopathy of neonatal rats

• Project/Area Number: 23659772
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Chiba University
• Principal Investigator: SHOZU Makio 千葉大学, 医学(系)研究科(研究院), 教授 (30226302)
• Co-Investigator(Renkei-kenkyūsha): OMOTO Akiko 千葉大学, 医学部附属病院, 助教 (60375764)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脳性麻痺 / 黄体ホルモン / ニューロステロイド / ラットモデル

Outline of Final Research Achievements

To assess neuroprotective actions of progestogen on neonatal rats, an experiment model, in which hypoxic-ischemic insult was applied during late pregnancy, was administered with progestogen after birth and was evaluated in terms of neurological performance and histological changes. We found that some progestogen improved locomotors function and prevented histological brain damage.

Research Products

• [Journal Article] ADAR1 induces adenosine-targeted DNA mutations in senescent Bcl6-deficient cells (2013)
  • Author(s): Tsuruoka, N., Arima, M., Yoshida, N., Okada, S., Sakamoto, A., Hatano, M., Satake, H., Arguni, E., Wang, J.-Y., Yang, J.-H., Nishikura, K., Sekiya, S., Shozu, M. and Tokuhisa, T.
  • Journal Title: J. Biol. Chem. Volume: 288 Issue: 2 Pages: 826-836
  • DOI: 10.1074/jbc.m112.365718
  • Peer Reviewed
• [Journal Article] Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion by targeting focal adhesion pathways in cervical squamous cell carcinoma (2013)
  • Author(s): Yamamoto N, Kinoshita T, Nohata N, Itesako T, Yoshino H, Enokida H, Nakagawa M, Shozu M, and Seki N
  • Journal Title: International journal of oncology Volume: 42 Issue: 5 Pages: 1523-1532
  • DOI: 10.3892/ijo.2013.1851
  • Peer Reviewed
• [Journal Article] Aromatase excess syndrome in a family with upstream deletion of CYP19A1 (2013)
  • Author(s): Shihara D, Miyado M, Nakabayashi K, Shozu M, Nagasaki K, Ogata T, Fukami M*
  • Journal Title: Clin Endocrinol, Volume: Epub ahead of print Issue: 2 Pages: 314-316
  • DOI: 10.1111/cen.12329
  • Peer Reviewed
• [Journal Article] Genomic basis of aromatase excess syndrome: recombination- and replication-mediated rearrangements leading to CYP19A1 overexpression. (2013)
  • Author(s): Fukami M*, Tsuchiya T, Vollbach H, Brown KA, Abe S, Ohtsu S, Wabitsch M, Gurger H, Sompson ER, Emezawa A, Nakabayashi K, Bulun SE, Shozu M, Ogata T
  • Journal Title: J Clin Endocrinol Metab Volume: 98 Issue: 12 Pages: E2013-E2021
  • DOI: 10.1210/jc.2013-2520
  • Peer Reviewed
• [Journal Article] A case of fetal goiter that resolved spontaneously after birth (2013)
  • Author(s): Omoto A, Kurimoto C, Minagawa M, Shozu M
  • Journal Title: J Clin Endocrinol Metab Volume: 98(10) Issue: 10 Pages: 3910-3911
  • DOI: 10.1210/jc.2013-1066
  • Peer Reviewed
• [Journal Article] Efficient subtractive cloning of genes activated by lipopolysaccharide and interferon γ in primary-cultured cortical cells of newborn mice. (2013)
  • Author(s): Miyauchi, O., Iwase, K., Itoh, K., Kato, M., Seki, N., Braissant, O., Bachmann, C., Shozu, M., Sekiya, S., Osada, H., and Takiguchi, M.
  • Journal Title: PLoS ONE Volume: 8 Issue: 11 Pages: e79236-e79236
  • DOI: 10.1371/journal.pone.0079236
  • Peer Reviewed
• [Journal Article] Aromatase excess syndromeas a model for genomic disorder: identification of molecular bases and phenotypic determinants (2013)
  • Author(s): Tsutomu Ogata, Makio Shozu and Maki Fukami
  • Journal Title: International Journal of Pediatric Endocrinology Volume: 2013(Suppl 1) Issue: S1
  • DOI: 10.1186/1687-9856-2013-s1-o20
  • Peer Reviewed
• [Journal Article] Acute Liver Failure Occurring during the First Trimester of Pregnancy Successfully Treated with Living Donor Liver Transplantation (2013)
  • Author(s): N. Kanogawa;T. Kanda;M. Ohtsuka;M. Nakamura;T. Miyamura;S. Yasui;M. Arai;H. Maruyama;K. Fujiwara;M. Shozu;S. Oda;M. Miyazaki;O. Yokosuka
  • Journal Title: Case Rep Transplant Volume: 2013 Pages: 309545-309545
  • DOI: 10.1155/2013/309545
  • Peer Reviewed
• [Journal Article] Expression of Angiotensin II receptor-like 1 (APJ) in teh Placentas of Pregnancy-Induced Hypertension (2012)
  • Author(s): Furuya M, Okuda M, Usui H, Takenouchi T, Kami D, Okuda M, Usui H, Takenouchi T, Kami D, Nozawa A, Shozu M, H, Takenouchi T, Kami D, Nozawa A, Shozu M, Umezawa, Takahashi A、Aoki
  • Journal Title: Int J Gynecol Pathol. Volume: 31（3） Pages: 227-35
  • Peer Reviewed
• [Journal Article] 特集・不妊診療のすべて 卵巣とアロマターゼ (2011)
  • Author(s): 生水真紀夫、碓井宏和
  • Journal Title: 産婦人科治療 Volume: 102
  • Peer Reviewed
• [Journal Article] 遺伝性女性化乳房症6家系における疾患成立機序と臨床像の解明 (2011)
  • Author(s): 深見真紀, 曽根田瞬, 加藤芙弥子, 花木啓一, 神埼晋, 大山建司, 佐野友昭, 西垣敏紀, 稲垣朱実, 高木博史, BinderGerhard, 横谷進, 堀川玲子, 生水真紀夫, 緒方勤
  • Journal Title: 日本内分泌学会雑誌 Volume: 87（Supplement) Pages: 94-97
  • Peer Reviewed
• [Presentation] 当院における水頭症を伴わない胎児脳室拡大症例19例の検討 (2012)
  • Author(s): 佐藤明日香、尾本暁子、真田通夫、岡山潤、山地沙知、中田恵美里、井上万里子、田中宏一、長田久夫、生水真紀夫、岩倉英雄
  • Organizer: 第48回日本周産期・新生児医学会総会および学術集会
  • Place of Presentation: 大宮
• [Presentation] エストロゲンによる間脳下垂体性腺系抑制機構の解明 アロマターゼ過剰症男性患者18例の分子遺伝学的および臨床的解析 (2011)
  • Author(s): 深見真紀, 生水真紀夫, 花木啓一, 佐野友昭, 西垣敏紀, 稲垣朱実, 高木博史, 堀川玲子, 神埼晋, 大山建司, 緒方勤
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸国際会議場
• [Presentation] アロマターゼ活性とその調節 (2011)
  • Author(s): 生水真紀夫
  • Organizer: 日本アンドロロジー学会第30回学術大会/第17回精子形成・精巣毒性研究会(招待講演)
  • Place of Presentation: 都市センターホテル(東京）
• [Presentation] 胎盤のアロマターゼが性差発現に果たす役割についての個体発生・系統発生学的研究 (2011)
  • Author(s): 生水真紀夫
  • Organizer: 新学術領域研究「性差構築の分子基盤」第3回領域会議(招待講演)
  • Place of Presentation: 国民宿舎虹ノ松原ホテル
• [Presentation] Aromatase inhibitorsによる排卵誘発の展望 (2011)
  • Author(s): 生水真紀夫
  • Organizer: 第29回日本受精着床学会総会・学術講演会(招待講演)
  • Place of Presentation: 京王プラザホテル（東京）
• [Presentation] 女性の生涯とアロマターゼ遺伝子 (2011)
  • Author(s): 生水真紀夫
  • Organizer: 第11回日本内分泌学会北海道地方会「女性医師専門医育成・再教育プロジェクト"JES We Can"企画セミナー」(招待講演)
  • Place of Presentation: 北翔大学北方圏学術情報センター
• [Presentation] エストロゲンと骨－思春期症例から (2011)
  • Author(s): 生水真紀夫
  • Organizer: 富山県産婦人科医会学術研修会(招待講演)
  • Place of Presentation: 富山県医師会館
• [Presentation] エストロゲンに纏わる新しい知見－アロマターゼがエストロゲンを合成するわけ－ (2011)
  • Author(s): 生水真紀夫
  • Organizer: 第5回阪神婦人科・内分泌研究会(招待講演)
  • Place of Presentation: 神戸ファッションマート
• [Presentation] ゲノム進化の謎に挑む：なぜ胎盤にアロマターゼが発現したか？ (2011)
  • Author(s): 生水真紀夫
  • Organizer: 日本人類遺伝学会第56回大会・第11回東アジア人類遺伝学会(招待講演)
  • Place of Presentation: 幕張メッセ国際会議場