| Project/Area Number |
23659781
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SUGINO Norihiro 山口大学, 医学(系)研究科(研究院), 教授 (10263782)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Akihiro 山口大学, 大学院医学系研究科, 准教授 (70379965)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 皮膚 / SCC / 扁平上皮 / E－カドヘリン / モーカドヘリン / カルシウム / 扁平上皮細胞 / カドヘリン / インボルクリン |
|---|
| Research Abstract |
This study was undertaken to investigate whether squamous cell carcinoma antigen (SCCA), which is well known as a tumor marker of SCC, has the abilities to stimulate production of cell-to-cell adhesion molecules and to maintain the structure of squamous epithelium. Expression of E-cadherin, a cell-to-cell adhesion molecule, was increased by incubation with calcium, accompanied by the morphological changes like epithelial cells in normal keratinocytes. These changes induced by calcium were abolished in the SCC cell lines in which SCCA expression was suppressed by transfection with the antisense cDNA of SCCA. These results suggest that SCCA contributes to the maintenance of the structure of squamous epithelium. The present study will be useful for the establishment of the novel treatment to promote skin maturation in preterm labor infants.
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