The role of a novel molecule in the regulation of reproductive system

• Project/Area Number: 23659782
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kyushu University
• Principal Investigator: HIRATA Masato 九州大学, 大学院・歯学研究院, 教授 (60136471)
• Co-Investigator(Renkei-kenkyūsha): MATSUDA Miho 九州大学, 大学院・歯学研究院, 助教 (40291520)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 生殖医学 / 性周期 / 性腺刺激ホルモン / 排卵 / 卵胞 / 生殖機能 / 卵胞成熟 / 性ホルモン / 性腺 / 遺伝子欠損マウス / 排卵障害

Research Abstract

This study revealed that PRIP plays an important role in femalereproductive system, particularly in gonadotropins secretion and in the regulation of ovarian follicle maturation and/or ovulation processes

Research Products

• [Journal Article] Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in mice (2013)
  • Author(s): Mizokami A., Yasutake Y., Gao J., Matsuda M., Takahashi I, Takeuchi H, Hirata M
  • Journal Title: PLoS ONE Volume: 8(2)
  • Peer Reviewed
• [Journal Article] PRIP (phospholipase C-related but catalytically inactive protein) inhibits exocytosis by direct interactions with syntaxin 1 and SNAP-25 through its C2 domain (2013)
  • Author(s): Zhang, Z.
  • Journal Title: The Journal of Biological Chemistry Volume: 288 Issue: 11 Pages: 7769-7780
  • DOI: 10.1074/jbc.m112.419317
  • Peer Reviewed
• [Journal Article] Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction. (2012)
  • Author(s): Kajioka S
  • Journal Title: Scientific Reports Volume: 2 Issue: 1 Pages: 979-979
  • DOI: 10.1038/srep00979
  • Peer Reviewed
• [Journal Article] Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation (2011)
  • Author(s): Tsutsumi K., Matsuda M., Kotani M., Mizokami A., Murakami A., Takahashi I., Terada Y., Kanematsu T., Fukami K., Takenawa T., Jimi E. and Hirata M
  • Journal Title: J Biol Chem Volume: 286 Pages: 31032-31042
  • Peer Reviewed
• [Journal Article] Involvement of PRIP, Phospholipase C-related, but Catalytically Inactive Protein, in Bone Formation (2011)
  • Author(s): Koshiro Tsutsumi
  • Journal Title: Journal of Biological Chemistry Volume: 286 Issue: 35 Pages: 31032-31042
  • DOI: 10.1074/jbc.m111.235903
  • Peer Reviewed
• [Journal Article] Phenotypes of pain behavior in phospholipase C-related but catalytically inactive protein type 1 knockout mice (2011)
  • Author(s): Migita K., Tomiyama M., Yamada J., Fukuzawa M., Kanematsu T., Hirata M., Ueno S
  • Journal Title: Molecular pain Volume: 7 Pages: 79-79
  • DOI: 10.1186/1744-8069-7-79
  • URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22008183
  • Peer Reviewed
• [Journal Article] Dual Signaling Pathways of Arterial Constriction by Extracellular Uridine 5'-Triphosphate in the Rat (2011)
  • Author(s): Sugihara M, Morita H, Matsuda M, Umebayashi H, Kajioka S, Ito S, Nishida M, Inoue R, Futatsuki T, Yamazaki J, Mori Y, Inoue R, Ito Y, Abe K, Hirata M
  • Journal Title: Journal of Pharmacological Sciences Volume: 115 Issue: 3 Pages: 293-308
  • DOI: 10.1254/jphs.10281FP
  • NAID: 10029892471
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Presentation] オステオカルシンはインクレチンの分泌を促進する (2012)
  • Author(s): 溝上顕子、安武 雄、平田雅人
  • Organizer: 第11回西日本骨・関節関連疾患懇話会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-07
• [Presentation] 生殖機構に欠かせない卵巣の機能における新規分子PRIPの役割 (2012)
  • Author(s): 松田美穂、平田雅人
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
• [Presentation] インクレチンを介したオステオカルシンの代謝への影響 (2012)
  • Author(s): 安武 雄、溝上顕子、平田雅人
  • Organizer: 第54回歯科基礎医学会学術大会
  • Place of Presentation: 福島
• [Presentation] Involvement of a novel signaling molecule, PRIP in the regulation of reproduction system (2012)
  • Author(s): Matsuda M., Kotani M., and Hirata M
  • Organizer: The 22th IUBMB, 37st FEBS Congress
  • Place of Presentation: Sevilla, Spain
• [Presentation] Role of a novel protein in alveolar bone remodeling mechanism of tooth movement (2012)
  • Author(s): Murakami A., Matsuda M., and Hirata M
  • Organizer: The 22th IUBMB, 37st FEBS Congress
  • Place of Presentation: Sevilla, Spain
• [Presentation] 骨芽細胞分化におけるPRIP の機能解析 (2012)
  • Author(s): 小谷美穂、松田美穂、平田雅人
  • Organizer: 日本生化学会九州支部例会
  • Place of Presentation: 福岡
• [Presentation] Involvement of a novel signaling molecule, PRIP in ovarian function for reproduction (2012)
  • Author(s): Matsuda, M.
  • Organizer: 第８５回日本生化学大会
  • Place of Presentation: 福岡国際センター
• [Presentation] Ovarian Function in PRIP deficient mice (2011)
  • Author(s): 松田美穂、平田雅人
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] PRIP is implicated in the negative regulation of bone formation (2011)
  • Author(s): Kotani M., Tsutsumi K., Matsuda M., and Hirata M
  • Organizer: The 10th JBS Biofrontier Symposium -New Aspects of Phospholipid Biology and Medicine 2011
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Osteocalcin triggers incretin secretion (2011)
  • Author(s): Nishioka T., Mizokami A, and Hirata M
  • Organizer: The 10th JBS Biofrontier Symposium -New Aspects of Phospholipid Biology and Medicine 2011
  • Place of Presentation: Fukuoka, Japan
• [Presentation] PRIP 遺伝子欠損マウスで観察された骨の表現型の解析 (2011)
  • Author(s): 堤康史郎、松田美穂、小谷美穂、溝上顕子、自見英治郎、平田雅人
  • Organizer: 第53回歯科基礎医学会学術大会
  • Place of Presentation: 岐阜
• [Presentation] 骨形成制御機構におけるPRIPの機能解析 (2011)
  • Author(s): 小谷美穂、堤康史郎、松田美穂、平田雅人
  • Organizer: 第84回日本生化学会年会
  • Place of Presentation: 京都
• [Presentation] 新規情報伝達分子PRIPノックアウトマウスにおける生殖制御の異常
  • Author(s): 松田美穂、平田雅人
  • Organizer: 第３４回日本分子生物学会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Remarks]
  • URL: http://www.mcb.dent.kyushu-u.ac.jp/index.html
• [Remarks] 九州大学大学院歯学研究院口腔細胞工学分野
  • URL: http://www.mcb.dent.kyushu-u.ac.jp/index.html
• [Remarks]
  • URL: http://www.mcb.dent.kyushu-u.ac.jp/