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Visualization of regenerated auditory nerves via cell transplantation

Research Project

Project/Area Number 23659794
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionKyoto University

Principal Investigator

ITO Juichi  京都大学, 医学研究科, 教授 (90176339)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Takayuki  京都大学, 医学研究科, 講師 (50335270)
TAURA Akiko  京都大学, 医学研究科, 助教 (70515345)
YAMAMOTO Norio  京都大学, 医学研究科, 助教 (70378644)
SAKAMOTO Tatsunori  京都大学, 医学研究科, 助教 (60425626)
KITAJIRI Shin-ichiro  京都大学, 医学研究科, 助教 (00532970)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経トレーサー / ラセン神経節 / 蝸牛神経核 / 細胞移植 / 機能的聴神経の再生
Research Abstract

This study aimed to develop methods for visualization of neural connections between the regenerated auditory nerve and central auditory system. Present results indicate the efficacy of biotinylated dextran amine as a tracer to visualize between neural connections between the inner ear and central auditory system.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Invited: 1 results) Book (4 results)

  • [Journal Article] 内耳再生へのストラテジー内耳障害の病態に応じた治療法の開発戦略2013

    • Author(s)
      中川隆之
    • Journal Title

      日薬理誌

      Volume: 141 Pages: 1-4

    • NAID

      10031165472

    • Related Report
      2012 Final Research Report
  • [Journal Article] 内耳再生へのストラテジー 内耳障害の病態に応じた治療法の開発戦略2013

    • Author(s)
      中川隆之
    • Journal Title

      日薬理誌

      Volume: 141 Pages: 184-187

    • NAID

      10031165472

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Fates of murine pluripotent stem cell-derived neural progenitors following transplantation into mouse cochleae2012

    • Author(s)
      Nishimura K, Nakagawa T, Sakamoto T, Ito J
    • Journal Title

      Cell Transplant

      Volume: 21 Pages: 763-771

    • NAID

      120004057181

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Trauma specific insults to the cochlear nucleus in the rat.2012

    • Author(s)
      Sekiya T, Viberg A, Kojima K, Sakamoto T, Nakagawa T, Ito J, Canlon B
    • Journal Title

      J Neurosci Res

      Volume: 90(10) Pages: 1924-31

    • Related Report
      2012 Final Research Report
  • [Journal Article] Trauma-specific insults to the cochlear nucleus in the rat.2012

    • Author(s)
      Tetsuji Sekiya
    • Journal Title

      J Neurosci Res.

      Volume: 90 Issue: 10 Pages: 1924-1931

    • DOI

      10.1002/jnr.23093

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 内耳再生医療開発と未来の難聴治療2013

    • Author(s)
      中川隆之
    • Organizer
      第68回山形県耳鼻咽喉科疾患研究会
    • Place of Presentation
      山形
    • Year and Date
      2013-03-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 内耳再生医療開発と未来の難聴治療

    • Author(s)
      中川隆之
    • Organizer
      第68回山形県耳鼻咽喉科疾患研究会
    • Place of Presentation
      山形医学 交流会館(山形市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] ここまで広がるドラッグ徐放技術の最前線 古くて新しいドラッグデリバリーシステム(DDS)2013

    • Author(s)
      坂本達則, 中川隆之, 伊藤壽一
    • Publisher
      ディカルドゥ
    • Related Report
      2012 Final Research Report
  • [Book] 内耳の幹細胞再生医療叢書2013

    • Author(s)
      中川隆之
    • Publisher
      朝倉書店
    • Related Report
      2012 Final Research Report
  • [Book] ここまで広がるドラッグ徐放技術の最前線 古くて新しいドラッグデリバリーシステム(DDS)2013

    • Author(s)
      坂本達則, 中川隆之, 伊藤壽一
    • Publisher
      メディカルドゥ
    • Related Report
      2012 Annual Research Report
  • [Book] 再生医療叢書 第4巻 上皮、感覚器2013

    • Author(s)
      中川隆之
    • Publisher
      朝倉書店
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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