Mechanism of sublingual immunotherapy -experimental approach in murine model-
| Project/Area Number |
23659796
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORIKURA Ichiro 島根大学, 医学部, 助教 (00362939)
AOI Noriaki 島根大学, 医学部, 講師 (80452556)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アレルギー性鼻炎 / ｽｷﾞ花粉症 / ｽｷﾞ花粉症治療米 / 舌下免疫療法 / regulatory T cells / ＩｇＥ抗体 / 調節性T細胞 / IgE抗体 / コレラトキシン / 経口免疫療法 / スギ花粉症 / スギ花粉症治療米 / 調節性Ｔ細胞 / ＣＴＢ / 制御性T細胞 / 抗原提示細胞 / サイトカイン |
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| Research Abstract |
To elucidate the mechanism of sublingual immunotherapy for allergic rhinitis, we have successfully constructed murine allergic rhinitis model with ovalbumin or cedar pollen as allergens. In this murine model, we demonstrated that sublingual immunotherapy at an induction phase actually attenuates nasal symptoms such as sneezing and nasal rubbing by downregulating allergen-specific IgE in sera. Moreover, allergen-specific regulatory T cells were induced in the cervical lymph node of mice sublingually immunized and these cells singnificantly produced IL-10
in an antigen-specific fashion.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Japanese traditional medicine, Senn-kinn-naidaku-sann upregulates Toll-like receptor 4 and reduce murine allergic rhinitis2014
Author(s)
Ichiro Morikura, Akemichi Murata, Noriaki Aoi, Yasuhiko Shimizu, Morikura, Akemichi Murata, Noriaki Aoi, Yasuhiko Shimizu, Takafumi Fuchiwaki, Emmanuel Prokopakis Murata, Noriaki Aoi, Yasuhiko Shimizu, Takafumi Fuchiwaki, Emmanuel Prokopakis, HIdeyuki Kawauchi
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Journal Title
Rhinology
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] The pathophysiology of the hygiene hypothesis2013
Author(s)
Emmanuel Prokopakis, Alexios Vardouniotis,Hideyuki Kawauchi, Glenis Scadding, Christos Georgalas, Peter Hellings, George Velegrakis,Livije Kalogjera
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Journal Title
International Journal of Pediatric otorhinolaryngolory
Volume: 77
Pages: 1065-1071
Related Report
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[Journal Article] The pathophysiology of the hygiene hypothesis2013
Author(s)
Emmanuel Prokopakis, Alexios Vardouniotis, Hideyuki Kawauchi, Glenis Scadding, Christos Georgalas, Peter Hellings, George Velegrakis, Livije Kalogjera
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Journal Title
International journal of pediatric otorhinolaryngology
Volume: 77
Pages: 1065-1071
Related Report
Peer Reviewed
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[Journal Article] Examination, diagnosis and classification for Japanese allergic rhinitis : Japanese guideline2012
Author(s)
Yuichi Kurono, Kimihiro Okubo, Keiichi Ichimura, Tadao Enomoto, Hideyuki Kawauchi, Keisuke Masuyama, Minoru Goto, Harumi Suzaki, Yoshitaka Okamoto, Hiroshi Takenaka
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Journal Title
Auris, nasus, larynx
Volume: 39(6)
Pages: 553-556
Related Report
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[Journal Article] Japanese traditional medicine, Senn-kinn-naidaku-sann up-regulates Toll-like receptor 4 and reduces murine allergic rhinitis2012
Author(s)
Ichiro Morikuraa, Akemichi Murataa,, Noriaki Aoia, Yasuhiko Shimizua, Takafumi Fuchiwakia,, Emmanuel prokopakisb,Hideyuki Kawauchia
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Journal Title
Rhinology, In Press
Volume: -
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[Book] Examination, diagnosis and classification for Japanese allergic rhinitis: Japanese guideline.2012
Author(s)
Shigeharu Fujieda, Yuichi Kurono, Kimihiro Okubo, Keiichi Ichimura, Tadao Enomoto, Hideyuki Kawauchi, Keisuke Masuyama, Minoru Goto, Harumi Suzaki, Yoshitaka Okamoto, Hiroshi Takenaka
Publisher
Auris, nasus, larynx
Related Report
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