| Project/Area Number |
23659796
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORIKURA Ichiro 島根大学, 医学部, 助教 (00362939)
AOI Noriaki 島根大学, 医学部, 講師 (80452556)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アレルギー性鼻炎 / ｽｷﾞ花粉症 / ｽｷﾞ花粉症治療米 / 舌下免疫療法 / regulatory T cells / ＩｇＥ抗体 / 調節性T細胞 / IgE抗体 / コレラトキシン / 経口免疫療法 / スギ花粉症 / スギ花粉症治療米 / 調節性Ｔ細胞 / ＣＴＢ / 制御性T細胞 / 抗原提示細胞 / サイトカイン |
|---|
| Research Abstract |
To elucidate the mechanism of sublingual immunotherapy for allergic rhinitis, we have successfully constructed murine allergic rhinitis model with ovalbumin or cedar pollen as allergens. In this murine model, we demonstrated that sublingual immunotherapy at an induction phase actually attenuates nasal symptoms such as sneezing and nasal rubbing by downregulating allergen-specific IgE in sera. Moreover, allergen-specific regulatory T cells were induced in the cervical lymph node of mice sublingually immunized and these cells singnificantly produced IL-10
in an antigen-specific fashion.
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