| Project/Area Number |
23659798
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kumamoto University |
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Principal Investigator |
YUMOTO Eiji 熊本大学, 大学院生命科学研究部, 教授 (40116992)
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| Co-Investigator(Renkei-kenkyūsha) |
SANUKI Tetsuji 熊本大学, 医学部附属病院, 講師 (10335896)
KUMAI Yoshihiko 熊本大学, 大学院生命科学研究部, 助教 (00555774)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 反回神経 / 過誤神経支配 / 共同運動 / 喉頭麻痺 / 脳・神経 |
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| Research Abstract |
Two animal groups were made: denervation (DNV) and reinnervation (Suture) groups. DNV animals did not show vocal fold movement. Some of Suture group animals showed synkinesis and others in the group showed weak physiological movement during respiration. Greater electromyographic recruitment of TA than PCA was seen during inhalation in the former, while recruitment of PCA was greater than TA during inhalation in majority of the latter subgroup.
Aberrant regeneration of nerve fibers in Suture group may have occurred, resulting in synkinesis of the VF depending on the degree of misdirection. Appearance of myosin heavy chain type IIA was not associated with the presence of synkinesis. Administration of Ca channel inhibitor, which facilitates axonal extension during regeneration, in Suture group did not result in decrease of synkinesis.
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