Diagnostic method by identifying specific T cell clone in Vogt-Koyanagi-Harada disease
| Project/Area Number |
23659803
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
KINOUCHI Reiko 旭川医科大学, 医学部, 特任准教授 (70344562)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | フォークト・小柳・原田病 / T細胞受容体 / CDR３ / Vogt-小柳-原田病 / Vogt-小柳ー原田病 |
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| Outline of Final Research Achievements |
We tried to identify specific T cell clone for Vogt-Koyanagi-Harada disease to establish diagnostic method. We found a clone which was seen in peripheral blood of 13 out of 17 VKH cases, while the clone was not seen in uveitis other than VKH and VKH after treatment. Though we performed qPCR detecting this clone to establish diagnostic methods, we could not detect the clone in VKH which developed after 2011. (We reported this results in the 119th annual meeting of the Japanese Ophthalmological Society, 2015.)
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Report
(5 results)
Research Products
(3 results)
