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Diagnostic method by identifying specific T cell clone in Vogt-Koyanagi-Harada disease

Research Project

Project/Area Number 23659803
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionAsahikawa Medical College

Principal Investigator

KINOUCHI Reiko  旭川医科大学, 医学部, 特任准教授 (70344562)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsフォークト・小柳・原田病 / T細胞受容体 / CDR3 / Vogt-小柳-原田病 / Vogt-小柳ー原田病
Outline of Final Research Achievements

We tried to identify specific T cell clone for Vogt-Koyanagi-Harada disease to establish diagnostic method. We found a clone which was seen in peripheral blood of 13 out of 17 VKH cases, while the clone was not seen in uveitis other than VKH and VKH after treatment. Though we performed qPCR detecting this clone to establish diagnostic methods, we could not detect the clone in VKH which developed after 2011. (We reported this results in the 119th annual meeting of the Japanese Ophthalmological Society, 2015.)

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Recurrent Vogt-Koyanagi-Harada disease with sensorineural hearing loss and choroidal thickening.2014

    • Author(s)
      Ishibazawa A, Kinouchi R, Minami Y, Katada A, Yoshida A.
    • Journal Title

      Int Ophthalmol.

      Volume: Epub ahead of print 2013 Issue: 3 Pages: 679-684

    • DOI

      10.1007/s10792-013-9849-9

    • NAID

      120005677798

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hypertensive choroidopathy with eclampsia viewed on spectral-domain optical coherence tomography.2013

    • Author(s)
      Song YS, Kinouchi R, Ishiko S, Fukui K, Yoshida A.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 251(11) Issue: 11 Pages: 2647-2650

    • DOI

      10.1007/s00417-013-2462-9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Vogt-小柳-原田病で増加するCD4陽性T細胞クローン2015

    • Author(s)
      木ノ内玲子、佐藤啓介、松本千恵美、小林博也、吉田晃敏
    • Organizer
      119回日本眼科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-04-16 – 2015-04-19
    • Related Report
      2014 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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