Artificial sight produced by transducing genes into primary visual cortex
| Project/Area Number |
23659804
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Iwate University (2012)
Tohoku University (2011) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUGANO Eriko 岩手大学, 工学部, 特任准教授 (70375210)
伊藤 拓哉 東北大学, 医学(系)研究科(研究院), 助教 (70396539)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 視覚再生 / 人工網膜 / チャネルロドプシン-2 / 遺伝子治療 / ウイルスベクター |
|---|
| Research Abstract |
The transduction efficiency to the cortex using AAV type 2/5 was higher than that using AAV2/2. However we could not succeed to transfer to the broad area. It was limited to the only injection site. We tested two types of AAVs including a CAG or CaMKII promoter. Different light responsivities elicited by ChR2 transferred cortex were recorded depending on the promoter the AAV included. These results indicated that it is important to choose appropriate promoter to transfer a gene into the cortex.
|
Report
(3 results)
Research Products
(52 results)
-
[Journal Article] Optogenetically Induced Seizure and the Longitudinal Hippocampal Network Dynamics2013
Author(s)
Osawa S, Iwasaki M, Hosaka R, Matsuzaka M, Tomita H, Ishizuka T, Sugano E, Okumura E, Yawo H, Nakasato N, Tominaga T, Mushiake H
-
Journal Title
PUBLIC LIBRARY OF SCIENCE ONE
Volume: 8(4)
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 視覚再生研究の新たな展開2011
Author(s)
日富田浩史, 菅野江里子, 砂金ひとみ, 王卓, 村山奈美枝, 玉井信
Organizer
日本眼科学会総会イヴニングセミナー
Place of Presentation
東京(東京国際フォーラム)
Year and Date
2011-05-13
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
