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Personal Made Immuno-therapy for Uveitis Using Regulatory T Cells

Research Project

Project/Area Number 23659807
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MOCHIZUKI Manabu  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (10010464)

Co-Investigator(Kenkyū-buntansha) SUGITA Sunao  理化学研究所, 網膜再生医療研究チーム, 研究員 (10299456)
TAKASE Hiroshi  東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (20451940)
鴨居 功樹  東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (40451942)
川口 龍史  東京医科歯科大学, 医学部, 非常勤講師 (90376707)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords眼免疫 / 免疫療法 / 制御性Tさいぼう / ぶどう膜炎 / 制御性T細胞
Research Abstract

Regulatory T cells (Treg) induced by retinal pigment epithelial cells strongly suppressed proliferation of active T cells and production of inflammatory cytokines by T cells. Furthermore, removing non-suppressive fraction of Treg exhibited much more intense suppressive activities. The suppressive fraction of Treg was capable of suppressing experimental autoimmune uveitis in mice. In human, Treg and suppressive fraction of Treg were induced similarly, but using pre-stimulation by TGF-b.These results indicate that Treg (or suppressive fraction of Treg) can be used for the treatment of non-infectious uveitis in human.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (14 results) (of which Invited: 2 results)

  • [Journal Article] Retinoic acid from retinal pigment epithelium induces T regulatory cells2012

    • Author(s)
      Kawazoe Y, Sugita S, Keino H, Yamada Y, Imai A, Horie S, Yamagami S, Mochizuki M
    • Journal Title

      Exp Eye Res

      Volume: 94 Pages: 32-40

    • Related Report
      2012 Final Research Report
  • [Journal Article] Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behcet's disease2012

    • Author(s)
      Sugita S, Kawazoe Y, Imai A, Yamada Y, Horie S, Mochizuki M
    • Journal Title

      Arthritis Res Ther

      Volume: 14

    • Related Report
      2012 Final Research Report
  • [Journal Article] Immunosuppressive properties of regulatory T cells generated by incubation of peripheral blood mononuclear cells with supernatants of human RPE cells2012

    • Author(s)
      Imai A, Sugita S, Kawazoe Y, Horie S, Yamada Y, Keino H, Maruyama K, Mochizuki M
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Pages: 7299-7309

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Immunological homeostasis of the eyes.2012

    • Author(s)
      Mochizuki M
    • Journal Title

      Prog Retin Eye Res.

      Volume: S1350-9462 Pages: 72-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinoic acid from retinal pigment epithelium induces T regulatory cells.2012

    • Author(s)
      Kawazoe Y
    • Journal Title

      xp Eye Res.

      Volume: 94 Pages: 32-40

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behcet's disease.2012

    • Author(s)
      Sugita S
    • Journal Title

      Arthritis Res Ther.

      Volume: 14

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of interleukin-17-producing T-helper 17 cells by retinal pigment epithelial cells.2011

    • Author(s)
      Sugita S, Horie S, Yamada Y, Kawazoe Y, Takase H, Mochizuki M.
    • Journal Title

      Jpn J Ophthalmol,

      Volume: 55 Pages: 565-575

    • NAID

      10029689229

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of corneal endothelial cells on IL-17-producing Th17 cells.2011

    • Author(s)
      Sugita S, Kawazoe Y, Yamada Y, Imai A, Horie S, Yamagami S, Mochizuki M.
    • Journal Title

      Br J Ophthalmol,

      Volume: 96 Pages: 293-299

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ベーチェット病に対するインフリキシマブ長期投与成績の検討2012

    • Author(s)
      川添裕子,鴨居功樹,宮永将,高瀬博,望月學
    • Organizer
      第66回日本臨床眼科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of regulatory T cells in uveitis2012

    • Author(s)
      Mochizuki M
    • Organizer
      8th International Symposium on Uveitis
    • Place of Presentation
      Thessaloniki (Greece)
    • Year and Date
      2012-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ベーチェット病ぶどう膜炎のTh22細胞の関与2012

    • Author(s)
      川添裕子,杉田直,今井彩乃,堀江真太郎,高瀬博,望月學
    • Organizer
      第46回日本眼炎症学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 網膜色素上皮細胞誘導制御性T細胞の実験的自己免疫性ぶどう膜炎の抑制2012

    • Author(s)
      今井彩乃,杉田直,川添裕子,堀江真太郎,慶野博,望月學
    • Organizer
      第46回日本眼炎症学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Inhibitory effect of regulatory T cellsexpanded in vitro by human retinal pigment epithelial (RPE) cells. Amyloid β enhances migration of endothelial progenitor cells via upregulation of CX3CR12012

    • Author(s)
      Sugita S, Kawazoe Y, Horei S, Yamada Y, Mochizuki M
    • Organizer
      The Association for Research in Visionand Ophthalmology AnnualMeeting
    • Place of Presentation
      Florida (U.S.A.)
    • Year and Date
      2012-05-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Immunosuppressive properties of retinal pigment epithelial (RPE)-induced regulatory T cells2012

    • Author(s)
      Mochizuki M
    • Organizer
      The Association for Research in Vision and Ophthalmology Annual Meeting
    • Place of Presentation
      Florida (U.S.A.)
    • Year and Date
      2012-05-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 網膜色素上皮細胞のレチノイン酸を介した制御性T細胞誘導.2011

    • Author(s)
      川添裕子, 杉田 直, 山田由季子, 堀江真太郎, 望月 學.
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 制御性T細胞を用いたぶどう膜炎免疫治療の可能性.2011

    • Author(s)
      今井彩乃, 杉田 直, 山田由季子, 川添裕子, 堀江真太郎, 高瀬 博, 望月 學.
    • Organizer
      第45回日本眼炎症学会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Immunosuppressive properties of retinal pigment epithelial (RPE)-induced regulatory T cells.

    • Author(s)
      Mochizuki M
    • Organizer
      The Association for Research in Vision and Ophthalmology Annual Meeting
    • Place of Presentation
      Florida (U.S.A.)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Role of regulatory T cells in uveitis.

    • Author(s)
      Mochizuki M
    • Organizer
      8th International Symposium on Uveitis
    • Place of Presentation
      Thessaloniki (Greece)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Inhibitory effect of regulatory T cells expanded in vitro by human retinal pigment epithelial (RPE) cells. Wang J, Ohno-Matsui K, Yoshida T, Shimada N, Mochizuki M, Morita I. Amyloid β enhances migration of endothelial progenitor cells via upregulation of CX3CR1.

    • Author(s)
      Sugita S
    • Organizer
      The Association for Research in Vision and Ophthalmology Annual Meeting
    • Place of Presentation
      Florida (U.S.A.)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ベーチェット病ぶどう膜炎のTh22細胞の関与.

    • Author(s)
      川添裕子
    • Organizer
      第46回日本眼炎症学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 網膜色素上皮細胞誘導制御性T細胞の実験的自己免疫性ぶどう膜炎の抑制.

    • Author(s)
      今井彩乃
    • Organizer
      第46会日本眼炎症学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] ベーチェット病に対するインフリキシマブ長期投与成績の検討.

    • Author(s)
      川添裕子
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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