| Project/Area Number |
23659808
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OHNO-MATSUI Kyoko 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (30262174)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Ikuo 東京医科歯科大学, 医歯学総合研究科, 教授 (60100129)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 加齢黄斑変性 / Amyloid β / 緑内障 / ラマン分光 / glaucoma / optic nerve / amyloid / アミロイドβ / アミロイドbeta / 網膜 / 視神経 / 多光子励起 |
|---|
| Research Abstract |
We previously demonstrated that Alzheimer's amyloid beta(Ab) was an important causative material for age-related macular degeneration (AMD). Recent studies showed Ab accumulation within retina in glaucoma. These suggest that Ab deposition might be a common precursors for both pathologies. To develop the methods of in vivo visualization of Ab deposited in the retina, we injected Ab into subretinal space of mouse eyes and injected the PiB; via tail vein. In retinal flatmount, subretinal Ab was clearly observed. However, the amount of Ab in the retina was not sufficient to be detected in neprilysin deficient mice. We also performed Raman spectroscopy to detect Ab in a non-invasive way.
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