| Project/Area Number |
23659810
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KOIZUMI Schuichi 山梨大学, 大学院・医学工学総合研究部, 教授 (10280752)
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| Co-Investigator(Kenkyū-buntansha) |
KASHIWAGI Kenji 山梨大学, 医学工学総合研究部, 准教授 (30194723)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 緑内障 / グリア細胞 / ミューラー細胞 / 網膜神経節細胞 / ATP / P2Y6受容体 / RGC / アストロサイト / P2受容体 / 突起伸展 |
|---|
| Research Abstract |
Effects of retinal glial cells (Muller cells and retinal astrocytes) on retinal ganglion neurons (RGCs) were investigated. Retinal glia, by releasing ATP or nucleotides, communicated with RGCs (MAN-network) to elongate the neurites. Responsible P2 receptor and intracellular signal for the elongation was P2Y6 receptor and Akt, respectively. Retinal glia had an important role in regulation of several RGCs’ functions including their elongation etc.
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