| Project/Area Number |
23659815
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MEGURO Akira 横浜市立大学, 医学研究科, 特任講師 (60508802)
KAWAGOE Tatsukata 横浜市立大学, 医学部, 助教 (20564800)
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| Co-Investigator(Renkei-kenkyūsha) |
SAWASAKI Tatsuya 愛媛大学, 無細胞生命科学工学研究センター, 教授 (50314969)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 眼生化学 / 分子生物学 / ベーチェット病 / インフリキシマブ / 薬剤応答 / 自己抗体 |
|---|
| Research Abstract |
The aim of this study was to investigate risk factors associated with non-response to infliximab treatment for Behcet’s disease. We found some candidate proteins associated with non-response to infliximab treatment using wheat cell-free protein synthesis technology. In addition, we found some candidate genes for non-response to infliximab treatment by assessing the genotypic data from the genome-wide association study.
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