| Project/Area Number |
23659823
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatric surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Shonosuke 筑波技術大学, 保健科学部, 准教授 (70359579)
SAKAKIBARA Yuzuru 筑波大学, 医学医療系, 教授 (60192085)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 先天性心疾患 / 高周波電位 / 小児開心術 / 先天性心大血管外科学 |
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| Research Abstract |
Basic research on development of clinically applicable non-invasive cardiac function monitor in children was conducted by analyzing changes in high-frequency QRS potentials on electrocardiogram during pediatric cardiac surgery. Changes in high-frequency QRS potentials was measured before and after removal of aortic cross-clamp and return of spontaneous heartbeat in pediatric patients undergoing cardiac surgery. Progressive recovery of high frequency QRS potentials was confirmed after reinstitution of myocardial perfusion and degree of high-frequency QRS potential recovery was correlated with improvement in cardiac function and degree of myocardial injury during surgical procedure. Our findings suggest that measurement of high-frequency QRS potentials on electrocardiogram after pediatric open heart surgery is a useful monitor of cardiac function and may have potentials to become an effective non-invasive cardiac function monitor in postoperative open heart surgical children.
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