| Project/Area Number |
23659825
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Plastic surgery
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
YAMAMOTO Yuhei 北海道大学, 大学院・医学研究科, 教授 (70271674)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FURUKAWA Hiroshi 北海道大学, 大学院・医学研究科, 講師 (00399924)
OYAMA Akihiko 北海道大学, 大学病院, 講師 (70374486)
FUNAYAMA Emi 北海道大学, 大学院・医学研究科, 助教 (10533630)
HAYASHI Toshihiko 北海道大学, 大学病院, 助教 (00432146)
SAITO Akira 北海道大学, 大学院・医学研究科, 非常勤講師 (70507574)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | ケロイド / 創傷治癒 / 増殖因子 / サイトカイン |
|---|
| Research Abstract |
HGF (hepatocyte growth factor) and TGF-β(transforming growth factor-β) often act antagonistically each other. For example, TGF-β accelerates liver fibrosis, whereas HGF prevents its progression. In our study, HGF suppressed type I collagen mRNA expression in keloid fibroblasts. HGF is suggested to repress TGF-β signal transduction pathway.
|
