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Controlled release of granulocyte colony-stimulating factor (G-CSF) enhances osteoconductive and biodegradable properties of beta-tricalcium phosphate (beta-TCP) in a rat calvarial defect model

Research Project

Project/Area Number 23659826
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionHokkaido University

Principal Investigator

OYAMA Akihiko  北海道大学, 大学病院, 講師 (70374486)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Yuhei  北海道大学, 大学院医学研究科, 教授 (70271674)
FURUKAWA Hiroshi  北海道大学, 大学院医学研究科, 講師 (00399924)
FUNAYAMA Emi  北海道大学, 大学院医学研究科, 助教 (10533630)
HAYASHI Toshikhiko  北海道大学, 大学院歯学研究科, 准教授 (00432146)
SAITO Akira  北海道大学, 大学院医学研究科, 客員研究員 (70507574)
Co-Investigator(Renkei-kenkyūsha) TABATA Yasuhiko  京都大学, 再生医科学研究所, 教授 (50211371)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords唇顎口蓋裂 / 再生医療 / G-CSF / 徐放化 / β-TCP / 骨欠損 / ゼラチンハイドロゲル / 骨再生 / 骨再生医療 / バイオセラミックス
Research Abstract

A total of 27 calvarial defects were randomly divided into nine treatment groups. One set of defects was filled with a beta-TCP disc containing normal saline alone (group-A, control) or 1 (group-B), 5 (group-C), or 20 ug of G-CSF saline solution (group-D). Another set of defects was filled with a beta-TCP disc with an overlaid gelatin hydrogel sheet incorporating normal saline alone (group-E), or 1 (group-F), 5 (group-G), or 20 ug of G-CSF solution (group-H). The last set of defects was left untreated (group-I). Histologic and histomorphometric analyses were performed at eight weeks postoperatively.
In groups F and G, values of newly formed bone were significantly higher compared to group A. The percentage of remaining beta-TCP in group G was significantly lower compared to group A.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2014 2013 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Controlled Release of Granulocyte Colony-Stimulating Factor Enhances Osteoconductive and Biodegradable Properties of Beta-Tricalcium Phosphate in a Rat Calvarial Defect Model2014

    • Author(s)
      Minagawa.T, Tabata.Y, Oyama.A, Furukawa.H, Yamao.T, Yamamoto.Y
    • Journal Title

      Int J Biomat

      Volume: Volume 2014 Pages: 11-11

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Controlled release of granulocyte colony-stimulating factor (G-CSF) enhances osteoconductive and biodegradable properties of beta-tricalcium phosphate in a rat calvarial defect model2014

    • Author(s)
      Tomohiro Minagawa, Yasuhiko Tabata, Akihiko Oyama, Hiroshi Furukawa, Takeshi Yamao, and Yuhei Yamamoto
    • Journal Title

      International Journal of Biomaterials

      Volume: 2014 Pages: 1-11

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Controlled release of G-CSF enhances osteoconductive and biodegradable properties of beta-TCP in a rat calvarial defect model2013

    • Author(s)
      皆川知広,田畑泰彦,小山明彦,古川洋志,山尾健,山本有平
    • Organizer
      第22回日本形成外科基礎学術集会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Related Report
      2013 Final Research Report
  • [Presentation] 徐放化G-CSFはbeta-tricalcium phosphate (β-TCP)の骨伝導能および生体吸収性を増幅する2013

    • Author(s)
      皆川知広,田畑泰彦,小山明彦,古川洋志,山尾健,山本有平
    • Organizer
      第22回日本形成外科学会基礎学術集会
    • Place of Presentation
      新潟コンベンションセンター(新潟県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 唇顎口蓋裂治療における再生医学~機能性scaffold を応用した顎裂再建2011

    • Author(s)
      皆川知広,田畑泰彦,小山明彦,古川洋志,山尾健,山本有平
    • Organizer
      23回北大形成外科アカデミー
    • Place of Presentation
      京王プラザホテル(札幌市)
    • Year and Date
      2011-12-10
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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