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Development of novel biotherapy using hybrid peptide targeting molecules on malignant melanoma

Research Project

Project/Area Number 23659827
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

SEKIDO Mitsuru  筑波大学, 医学医療系, 教授 (40372255)

Co-Investigator(Kenkyū-buntansha) ISHIGE Kazunori  筑波大学, 医学医療系, 講師 (20597918)
SHODA Junichi  筑波大学, 医学医療系, 教授 (90241827)
TAKEUCHI Kaoru  筑波大学, 医学医療系, 准教授 (00192162)
KAWAKAMI Koji  京都大学, 医学系研究科, 教授 (70422318)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords悪性黒色腫 / サイトカイン / 受容体 / 標的治療 / バイオ療法
Research Abstract

Interleukin-4 receptor (IL-4R) is highly expressed on the surface of various human solid tumors including head and neck squamous cell carcinoma (HNSCC). Recently, we designed a novel IL-4R-lytic hybrid peptide composed of a binding peptide to IL-4R and a cell-lytic peptide. We confirmed the antitumor activity of the IL-4R-lytic hybrid peptide as a novel molecular-targeted therapy in several kinds of cancers. Malignant melanoma is a challenging cancer with poorer survival outcome. In addition, oral cavity cancer is also a challenging cancer in its advanced cases. In this study, we evaluated the antitumor activity of the IL-4R-lytic hybrid peptide as a novel molecular-targeted therapy in malignant melanoma and oral cavity cancers. IL-4R was expressed in oral cavity cancer cell lines, but not in a human normal keratinocyte. IL-4R in oral cavity cancer tissue was higher compared to that in normal epithelial tissue. The results revealed the antitumor activity of the IL-4R-lytic hybrid peptide against oral cavity cancers in a dose-dependent manner using the in vitro and in vivo experiments. However, we did not confirm the antitumor activity against malignant melanoma.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (36 results)

All 2013 2012 2011

All Journal Article (24 results) (of which Peer Reviewed: 24 results) Presentation (5 results) Book (7 results)

  • [Journal Article] Presurgical Orthopedic Treatment Ameliorates Postoperative Nasal Deformity after Cheiloplasty2013

    • Author(s)
      Adachi K, Togashi S, Yanagawa T, Ishibashi N, Goto T, Yamagata K, Onizawa K, Sasaki H, Sasaki K, Bukawa H, Sekido M
    • Journal Title

      Annals of Plastic Surgery

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exercise training decreases elevated serum ferritin and lipid peroxidation marker levels in middle-aged obese men with non-alcoholic fatty liver disease2013

    • Author(s)
      Oh S, Tanaka K, Warabi E, Shoda J
    • Journal Title

      Medicine & Science in Sports & Exercise

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma2013

    • Author(s)
      Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, Kohno M, Yanagawa T, Bukawa H, Kawakami K
    • Journal Title

      Oncology Report

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder2013

    • Author(s)
      Onuki K,Sugiyama H,Ishige K, Kawamoto T,Ota T,Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M,Miyoshi E,Shoda J
    • Journal Title

      J Gastroenterol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma.2013

    • Author(s)
      Kaori Seto
    • Journal Title

      Oncology Report

      Volume: xx Issue: 6 Pages: 2147-2153

    • DOI

      10.3892/or.2013.2387

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.2013

    • Author(s)
      Kenichiro Onuki
    • Journal Title

      J Gastroenterol

      Volume: 48 Issue: 4 Pages: 702-714

    • DOI

      10.1007/s00535-013-0813-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transverse fascial suspension with muscle bow traction: Advantages for full-thickness lip reconstruction involving the oral commissure using free flap2012

    • Author(s)
      Sasaki K, Adachi K, Sakido M
    • Journal Title

      Journal of Plastic, Reconstructive &Aesthetic Surgery

      Volume: 65

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Technique to Improve the Geometric and Unnatural Appearance of the Inferior Triangular Flap in Primary Unilateral Cleft Lip Repair Plastic and Reconstructive2012

    • Author(s)
      Todgashi S, Sekido M
    • Journal Title

      Surgery

      Volume: 129

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of collagen arrangement change during tendon healing demonstrated by scanning electron microscopy2012

    • Author(s)
      Sasaki K, Yamamoto N, Kiyosawa T, Sekido M
    • Journal Title

      ournal of Electron Microscopy

      Volume: 61 Pages: 327-334

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biliary tract carcinoma: clinical perspective on molecular targeting strategies for therapeutic options2012

    • Author(s)
      Shoda J, Ishige K, Sugiyama H, Kawamoto T
    • Journal Title

      JHBPS

      Volume: 19 Pages: 342-353

    • NAID

      10030950703

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CAD/CAMによる3D造形モデルを用いた下顎骨再建の3例2012

    • Author(s)
      福田麻衣子,新谷佳子,柳川 徹,山城拓也,櫻井陽子,佐々木薫,足立孝二,鬼澤浩司郎,関堂 充,武川寛樹
    • Journal Title

      茨城県歯科医学会誌

      Volume: 20 Pages: 40-41

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 舌亜全摘以上の欠損に対する機能的再建法2012

    • Author(s)
      関堂 充, 足立孝二, 佐々木薫, 富樫真二, 斉藤 亮, 古川洋志, 山本有平
    • Journal Title

      形成外科

      Volume: 55 Pages: 23-29

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] われわれが経験した合趾症手術例の検討2012

    • Author(s)
      會沢哲士, 芳賀康史, 富樫真二, 中山凱夫, 関堂 充
    • Journal Title

      日形会誌

      Volume: 32 Pages: 450-457

    • NAID

      10030954059

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 保存的治療で軽快したVibrio vulnificus 感染症の1例2012

    • Author(s)
      小林友哉, 玉田崇和, 足立孝二, 関堂充
    • Journal Title

      日形会誌

      Volume: 32 Pages: 486-488

    • NAID

      10030954162

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 手術点数から算定したチームサージャリーにおける形成外科科の貢献-2010年度保険診療点数改正の影響-2012

    • Author(s)
      佐々木 薫, 足立 孝二, 棚倉 健太, 富樫 真二, 関堂 充
    • Journal Title

      日形会誌

      Volume: 32 Pages: 542-547

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小耳症助軟骨移植後の軟骨露出に対する陰圧閉鎖療法の有用性2012

    • Author(s)
      江藤 綾乃, 佐々木 薫, 富樫 真二, 會沢 哲士, 関堂 充
    • Journal Title

      日形会誌

      Volume: 32 Pages: 686-689

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 死腔, 血腫の防止1)ドレーンの目的と選択 2)陰圧吸引ドレーンの適応と抜去時期2012

    • Author(s)
      関堂 充, 富樫真二
    • Journal Title

      形成外科

      Volume: 55 Pages: 34-40

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 血管吻合が有効であった手掌デグロービング損傷の1 例2012

    • Author(s)
      佐々木薫, 久保 諭, 関堂 充, 清澤智晴, 武石 明精
    • Journal Title

      日形会誌

      Volume: 32 Pages: 841-845

    • NAID

      10031129807

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 筑波大学における乳房再建外来新設の効果2012

    • Author(s)
      赤澤俊文, 関堂 充, 佐々木薫, 足立孝二, 坂東 裕子
    • Journal Title

      日形会誌

      Volume: 33 Pages: 887-891

    • NAID

      10031144543

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 乳房再建における移植床血管としての胸背動静脈前鋸筋枝の有用性2012

    • Author(s)
      川井啓太, 関堂 充, 佐々木薫, 足立孝二, 富樫真二
    • Journal Title

      日本マイクロサージャリー学会会誌

      Volume: 25 Pages: 201-206

    • NAID

      130004843264

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amelioration of cisplatin- induced nephrotoxicity in Peroxiredoxin I- deficient mice.2012

    • Author(s)
      Kosuke Okada
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 71 Issue: 2 Pages: 503-509

    • DOI

      10.1007/s00280-012-2046-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] clinical perspective on molecular targeting strategies for therapeutic options.2012

    • Author(s)
      Shoda J, Ishige K, Sugiyama H, Kawamoto T: Biliary tract carcinoma
    • Journal Title

      JHBPS

      Volume: 19 Issue: 4 Pages: 342-353

    • DOI

      10.1007/s00534-012-0520-z

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orexin 2 receptor as a potential target for immunotoxin and antibody-drug2012

    • Author(s)
      Kishida M, et al.
    • Journal Title

      Oncology letters

      Volume: 3 Issue: 3 Pages: 525-529

    • DOI

      10.3892/ol.2011.528

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells.2011

    • Author(s)
      Sugiyama H, Onuki K, Ishige K, Baba N, Ueda T, Matsuda S, Takeuchi K, OnoderaM,Nakanuma Y,Yamato M, Yamamoto M, Hyodo I, Shoda J
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 779-789

    • NAID

      10029029679

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 口腔がんにおける糖転移酵素GnT- Vの機能解析(転移性因子として)2013

    • Author(s)
      内田文彦
    • Organizer
      第31回口腔腫瘍学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 疾病モデルより解明された肝病態に対する転写因子Nrf2の演じる生体防御機構2012

    • Author(s)
      岡田浩介,蕨 栄治,正田純一
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Nrf2/p62遺伝子二重欠損マウスは脂肪性肝炎を自然発症し,肝腫瘍を発生する2012

    • Author(s)
      岡田浩介,蕨 栄治,徳重克年,石井哲郎,橋本悦子,正田純一
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Final Research Report
  • [Presentation] 胆石の種類と成因.日本胆道学会認定指導医養成講座32012

    • Author(s)
      正田純一
    • Organizer
      第48回日本胆道学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 胆管がんに対するハイブリッドペプチドの新しいバイオ療法 厚生労働科学研究費補助金 難治性疾患克服研究事業2012

    • Author(s)
      正田純一
    • Organizer
      難治性の肝・胆道疾患に関する調査研究
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Book] Horizons in Cancer Research. Volume 482013

    • Author(s)
      Junichi Soda
    • Total Pages
      33
    • Publisher
      NOVA Science
    • Related Report
      2012 Annual Research Report
  • [Book] 統合医療を推進するための日本伝統医学の標準化2012

    • Author(s)
      漢方
    • Related Report
      2012 Final Research Report
  • [Book] Health and Labour Sciences Research Grant2012

    • Author(s)
      Shoda J
    • Related Report
      2012 Final Research Report
  • [Book] Gallbladder Cancer Pathogenesis and Molecular Targeting Strategies for Therapeutic Options2012

    • Author(s)
      Shoda J & Yamamoto M
    • Publisher
      NOVA Science
    • Related Report
      2012 Final Research Report
  • [Book] extbook of Traditional Japanese Medicine2012

    • Author(s)
      Junichi Shoda
    • Total Pages
      3
    • Publisher
      Ministry of Health, Labour and Welfare
    • Related Report
      2012 Annual Research Report
  • [Book] 胆石症・胆道炎・胆道がん 胆石症 概念・定義と疫学2011

    • Author(s)
      正田純一
    • Publisher
      最新医学社(大阪)
    • Related Report
      2012 Final Research Report
  • [Book] Annual Review 消化器2011

    • Author(s)
      正田純一
    • Publisher
      胆道癌発生の分子機序
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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