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Investigation of nerve regeneration and its plasticity using a new antibodies against phosphorylated GAP-43 (p-GAP-43)

Research Project

Project/Area Number 23659830
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionNiigata University

Principal Investigator

SHIBATA Minoru  新潟大学, 医歯学系, 教授 (50196432)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsp-GAP-43 / end to side coaptation / epineurial window / nerve injury / perineurial window / RT 97 / 抗GAP-43抗体
Research Abstract

Histological changes were observed in peripheral nerves following end-to-side nerve coaptation to determine the effects of perineurial opening and deliberate donor nerve injury during surgery. Seven days after coaptation of the musculocutaneous (recipient) nerve to the ulnar (donor) nerve, the nerves were immunohistochemically analysed using antibodies against neurofilament-H (RT97) and phosphorylated GAP-43 (p-GAP-43). The latter was found to detect specifically generating nerve fibers. Statistical evaluation revealed increased efficacy of perineurial opening and deliberate donor nerve injury in end-to-side nerve coaptation, suggesting that partial nerve fiber herniation with partial axonotmesis or neurotomesis was important for effective axonal regeneration in end-to-side nerve coaptation.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2013 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Morphological assessment of early axonal regeneration in end-to-side nerve coaptation models.2012

    • Author(s)
      Oyamatsu H, Koga D, Igarashi M, S h ib a ta M, Ushiki T.
    • Journal Title

      J Plast Surg Hand Surg.

      Volume: 46(5) Pages: 299-307

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 神経端側吻合モデルにおける軸索再生早期の形態学的分析(学術奨励賞受賞講演)2013

    • Author(s)
      親松宏
    • Organizer
      第56回形成外科学会総会
    • Place of Presentation
      東京京王プラザホテル(招待講演).
    • Year and Date
      2013-04-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経端側吻合モデルにおける軸索再生早期の形態学的分析(学術奨励賞受賞講演)

    • Author(s)
      親松 宏
    • Organizer
      第56回形成外科学会総会
    • Place of Presentation
      東京 京王プラザホテル
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2011-08-05   Modified: 2019-07-29  

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