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Preparation of chondrocyte aggregates with gelatin microspheres to promote cartilage regeneration.

Research Project

Project/Area Number 23659831
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionKyoto University

Principal Investigator

KAWAI Katsuya  京都大学, 医学(系)研究科(研究院), 准教授 (90273458)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords再生医学 / 国際情報交流
Research Abstract

This study developed a novel 3D culture procedure; chondrocyte aggregates with gelatin microspheres to promote cartilage regeneration.The viability of chondrocytes and the sulfated glycosaminoglycan production of chondrocytes in an aggregate with microspheres were significantly higher compared with that of aggregate without microspheres. This result indicated that chondrocyte aggregates with microspheres enhanced chondrogenic differentiation in vitro. Moreover, in vivo implantation study, the area of regenerated cartilaginous tissue in the group of chondrocyte aggregates with microspheres was larger than that of chondrocyte aggregates without microspheres. In conclusion, this novel procedure may allow for the development of cartilage regeneration.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2014

All Presentation (2 results)

  • [Presentation]2014

    • Author(s)
      中村陽子 河合勝也 内藤素子 鈴木茂彦
    • Organizer
      第13回日本再生医療学会
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体吸収性ハイドロゲル粒子含有細胞集合体を用いた三次元培養による軟骨再生2014

    • Author(s)
      中村陽子 河合勝也 内藤素子 鈴木茂彦
    • Organizer
      第13回 日本再生医療学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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