| Project/Area Number |
23659841
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Kazuo 千葉大学, 大学院・医学研究院, 特任教授 (20192130)
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| Co-Investigator(Renkei-kenkyūsha) |
AOYAGI Tetsuji 東北大学, 大学院・医学系研究科, 助教 (50581609)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ARDS / インフルエンザ / タイトジャンクション / クローディン / 気管支上皮細胞 / 血管内皮細胞 / 炎症細胞 |
|---|
| Research Abstract |
We addressed the possible involvement of claudins in the development of acute lung injury. In a real-time PCR analysis, expression of cluadin 2 and 4 was increased in the injured lungs, whereas that of claudin 5, 6, 9 and 18-1 was reduced. In an immunohistochemical analysis, expression of claudin 2 and 4 was detected in the bronchoepithelial cells of injured lungs. Lung edema caused by LPS administration tended to be worsened in claudin4 gene-disrupted mice. These results suggest that claudins may be involved in thedevelopment of ARDS.
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